Near-Infrared Laser Adjuvant for Influenza Vaccine

被引：33

作者：

Kashiwagi, Satoshi ^{[1
]}

Yuan, Jianping ^{[1
]}

Forbes, Benjamin ^{[1
]}

Hibert, Mathew L. ^{[1
]}

Lee, Eugene L. Q. ^{[1
]}

Whicher, Laura ^{[1
]}

Goudie, Calum ^{[1
]}

Yang, Yuan ^{[1
]}

Chen, Tao ^{[1
]}

Edelblute, Beth ^{[1
]}

Collette, Brian ^{[1
]}

Edington, Laurel ^{[1
]}

Trussler, James ^{[1
]}

Nezivar, Jean ^{[1
]}

Leblanc, Pierre ^{[1
]}

Bronson, Roderick ^{[2
]}

Tsukada, Kosuke ^{[3
]}

Suematsu, Makoto ^{[4
]}

Dover, Jeffrey ^{[5
]}

Brauns, Timothy ^{[1
]}

Gelfand, Jeffrey ^{[1
]}

Poznansky, Mark C. ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Dept Med, Vaccine & Immunotherapy Ctr, Div Infect Dis, Charlestown, MA 02129 USA

[2] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

[3] Keio Univ, Fac Sci & Technol, Dept Appl Phys & Physicoinformat, Kohoku Ku, Yokohama, Kanagawa 223, Japan

[4] Keio Univ, Sch Med, Dept Biochem, Shinjuku Ku, Tokyo, Japan

[5] SkinCare Phys Chestnut Hill, Chestnut Hill, MA USA

来源：

PLOS ONE | 2013年 / 8卷 / 12期

基金：

比尔及梅琳达.盖茨基金会;

关键词：

INTRADERMAL VACCINE; MF59-ADJUVANTED INFLUENZA; PROTECTIVE IMMUNITY; VIRUS VACCINE; MUCOSAL; IMMUNOGENICITY; IMMUNIZATION; DELIVERY; SAFETY; MICE;

D O I：

10.1371/journal.pone.0082899

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Safe and effective immunologic adjuvants are often essential for vaccines. However, the choice of adjuvant for licensed vaccines is limited, especially for those that are administered intradermally. We show that non-tissue damaging, near-infrared (NIR) laser light given in short exposures to small areas of skin, without the use of additional chemical or biological agents, significantly increases immune responses to intradermal influenza vaccination without augmenting IgE. The NIR laser-adjuvanted vaccine confers increased protection in a murine influenza lethal challenge model as compared to unadjuvanted vaccine. We show that NIR laser treatment induces the expression of specific chemokines in the skin resulting in recruitment and activation of dendritic cells and is safe to use in both mice and humans. The NIR laser adjuvant technology provides a novel, safe, low-cost, simple-to-use, potentially broadly applicable and clinically feasible approach to enhancing vaccine efficacy as an alternative to chemical and biological adjuvants.

引用

页数：15

共 67 条

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