Regio- and Stereoselective Copper-Catalyzed Allylation of 1,3-Dicarbonyl Compounds with Terminal Allenes

被引：24

作者：

Blieck, Remi ^{[1
]}

Abdine, Racha Abed Ali ^{[1
]}

Taillefer, Marc ^{[1
]}

Monnier, Florian ^{[1
,2
]}

机构：

[1] Ecole Natl Super Chim Montpellier, Inst Charles Gerhardt Montpellier, CNRS, UMR 5253,AM2N, 8 Rue Ecole Normale, F-34296 Montpellier 5, France

[2] IUF, 1 Rue Descartes, F-75231 Paris 5, France

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 08期

关键词：

REGIOSELECTIVE ACCESS; HYDROAMINATION; ALKYNES; PRONUCLEOPHILES; HYDROALKOXYLATION; CONSTRUCTION; AMINES; HYDROCARBONATION; ALKOXYALLENES; TERTIARY;

D O I：

10.1021/acs.orglett.8b00575

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Simple ligand-free copper systems were found as efficient catalysts for the addition of 1,3-dicarbonyl compounds to N-allenyl derivatives. This highly regio- and stereoselective reaction has been accomplished in the presence of malonates, 1,3-ketoesters, and 1,3-diketones with good to excellent yields under mild conditions. This methodology represents the first allylation of 1,3-dicarbonyl compounds with allenes catalyzed by copper.

引用

页码：2232 / 2235

页数：4

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