Treatment of epilepsy in patients with Alzheimer's disease

被引：19

作者：

Giorgi, Filippo Sean ^{[1
]}

Guida, Melania ^{[1
]}

Vergallo, Andrea ^{[1
]}

Bonuccelli, Ubaldo ^{[1
]}

Zaccara, Gaetano ^{[2
]}

机构：

[1] Univ Pisa, Dept Clin & Expt Med, Neurol Unit, Pisa Univ Hosp, Pisa, Italy

[2] Florence Hlth Author, Neurol Unit, Dept Med, Florence, Italy

来源：

EXPERT REVIEW OF NEUROTHERAPEUTICS | 2017年 / 17卷 / 03期

关键词：

Alzheimer's disease; antiepileptic drugs; complex partial seizures; dementia; EEG; elderly patients; epilepsy; focal epilepsy; generalized epilepsy; pharmacokinetics; NEWLY-DIAGNOSED EPILEPSY; CHRONIC DIVALPROEX SODIUM; ANTIEPILEPTIC DRUG-USE; LATE-ONSET SEIZURES; ELDERLY-PATIENTS; DOUBLE-BLIND; COGNITIVE FUNCTION; LEVETIRACETAM MONOTHERAPY; NETWORK DYSFUNCTION; INDUCED CONVULSIONS;

D O I：

10.1080/14737175.2017.1243469

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: Epilepsy is significantly more frequent in AD patients than in age-matched controls, even though the true extent of the phenomenon is not clear yet.Areas covered: In this review, we describe in detail the available data on the pharmacological treatment of epilepsy in patients with AD. We also briefly describe general principles of AEDs use in elderly, as well as the potential cognitive profile of AEDs and safety of concomitant psychotropic drugs in patients with epilepsy and AD.Expert commentary: As some preclinical data suggest a role of epileptiform discharges in cognitive decline in AD, a prompt diagnosis and treatment of seizures in these patients should be pursued. The few data on the use of AEDs in AD patients suggest that newer AEDs (in particular lamotrigine and levetiracetam) might be good choices. Experimental data even support a potential role of some AEDs in modifying the disease course of AD.

引用

页码：309 / 318

页数：10

共 50 条

[41] Do Epilepsy Patients with Cognitive Impairment Have Alzheimer's Disease-like Brain Metabolism?
He, Michael
Kolesar, Tiffany A.
Goertzen, Andrew L.
Ng, Marcus C.
Ko, Ji Hyun
BIOMEDICINES, 2023, 11 (04)
[42] Pharmacological treatment for older adults with epilepsy and comorbid neurodegenerative disorders
O'Dwyer, Rebecca
Foster, Emma
Leppik, Ilo
Kwan, Patrick
CURRENT OPINION IN NEUROLOGY, 2023, 36 (02) : 117 - 123
[43] Predictors and Moderators of Quality of Life in Alzheimer's Disease Patients
Lima, Sara
Gago, Miguel
Garrett, Carolina
Graca Pereira, M.
JOURNAL OF ALZHEIMERS DISEASE, 2016, 54 (03) : 1113 - 1121
[44] Clinical efficacy and safety of donepezil in the treatment of Alzheimer's disease in Chinese patients
Zhang, Nan
Gordon, Marc L.
CLINICAL INTERVENTIONS IN AGING, 2018, 13 : 1963 - 1970
[45] Alzheimer's Disease and Epilepsy: A Perspective on the Opportunities for Overlapping Therapeutic Innovation
Lehmann, Leanne
Lo, Alexandria
Knox, Kevin M.
Barker-Haliski, Melissa
NEUROCHEMICAL RESEARCH, 2021, 46 (08) : 1895 - 1912
[46] Pharmacotherapeutic combinations for the treatment of Alzheimer's disease
Nagata, Tomoyuki
Shinagawa, Shunichiro
Nakajima, Shinichiro
Noda, Yoshihiro
Mimura, Masaru
EXPERT OPINION ON PHARMACOTHERAPY, 2022, 23 (06) : 727 - 737
[47] Update on the Pharmacological Treatment of Alzheimer's Disease
Massoud, Fadi
Gauthier, Serge
CURRENT NEUROPHARMACOLOGY, 2010, 8 (01) : 69 - 80
[48] Pharmacologic treatment of depression in Alzheimer's disease
Haussmann, Robert
Donix, Markus
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, 2023, 38 (02) : 81 - 88
[49] Somatic comorbidities and Alzheimer's disease treatment
Clodomiro, Alessandra
Gareri, Pietro
Puccio, Gianfranco
Frangipane, Francesca
Lacava, Roberto
Castagna, Alberto
Manfredi, Valeria Graziella Laura
Colao, Rosanna
Bruni, Amalia Cecilia
NEUROLOGICAL SCIENCES, 2013, 34 (09) : 1581 - 1589
[50] Transdermal rivastigmine in the treatment of Alzheimer's disease: current and future directions
Amanatkar, Hamid Reza
Grossberg, George Thomas
EXPERT REVIEW OF NEUROTHERAPEUTICS, 2014, 14 (10) : 1119 - 1125

← 1 2 3 4 5 →