Successful Treatment of Persistent Burkholderia cepacia Complex Bacteremia with Ceftazidime-Avibactam

被引：1
作者：
Tamma, Pranita D. [1 ]
Fan, Yunfan [2 ]
Bergman, Yehudit [3 ]
Sick-Samuels, Anna C.
Hsu, Alice J. [4 ]
Timp, Winston [2 ]
Simner, Patricia J. [3 ]
Prokesch, Bonnie C. [5 ]
Greenberg, David E. [5 ,6 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21205 USA
[2] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD USA
[3] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA
[4] Johns Hopkins Univ Hosp, Dept Pharm, Baltimore, MD 21287 USA
[5] Univ Texas Southwestern, Div Infect Dis, Dallas, TX 75390 USA
[6] Univ Texas Southwestern, Dept Microbiol, Dallas, TX 75390 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2018年 / 62卷 / 04期
基金：
美国国家卫生研究院;
关键词：
Burkholderia cepacia complex; whole-genome sequencing; bacteremia; ceftazidime-avibactam; BETA-LACTAMASES; CYSTIC-FIBROSIS; SUSCEPTIBILITY; INFECTIONS; RESISTANCE; BLOOD;
D O I：
10.1128/AAC.02213-17
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We report our clinical experience treating a 2-month-old infant with congenital diaphragmatic hernia who experienced prolonged bacteremia with Burkholderia cepacia complex (Bcc) despite conventional antibiotic therapy and appropriate source control measures. The infection resolved after initiation of ceftazidime-avibactam. Whole-genome sequencing revealed that the isolate most closely resembled B. contaminans and identified the mechanism of resistance that likely contributed to clinical cure with this agent. Ceftazidime-avibactam should be considered salvage therapy for Bcc infections if other treatment options have been exhausted.
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页数：7
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