Longitudinal changes of brain microstructure and function in nonconcussed female rugby players

被引:22
作者
Manning, Kathryn Y. [1 ,8 ]
Brooks, Jeffrey S. [2 ]
Dickey, James P. [2 ]
Harriss, Alexandra [4 ]
Fischer, Lisa [10 ]
Jevremovic, Tatiana [10 ]
Blackney, Kevin [3 ,9 ]
Barreira, Christy [9 ]
Brown, Arthur [5 ,9 ]
Bartha, Robert [1 ,8 ]
Doherty, Tim [6 ]
Fraser, Douglas [11 ]
Holmes, Jeff [7 ]
Dekaban, Gregory A. [9 ]
Menon, Ravi S. [1 ,8 ]
机构
[1] Western Univ, Med Biophys, London, ON, Canada
[2] Western Univ, Sch Kinesiol, London, ON, Canada
[3] Western Univ, Microbiol & Immunol, London, ON, Canada
[4] Western Univ, Hlth & Rehabil Sci, London, ON, Canada
[5] Western Univ, Anat & Cell Biol, London, ON, Canada
[6] Western Univ, Phys Med & Rehabil, London, ON, Canada
[7] Western Univ, Sch Occupat Therapy, London, ON, Canada
[8] Robarts Res Inst, Ctr Funct & Metab Mapping, London, ON, Canada
[9] Robarts Res Inst, Mol Med Res Labs, London, ON, Canada
[10] Fowler Kennedy Sport Med, Primary Care Sport Med, London, ON, Canada
[11] London Hlth Sci Ctr, Paediat Crit Care Med, London, ON, Canada
基金
加拿大自然科学与工程研究理事会;
关键词
COLLEGIATE FOOTBALL PLAYERS; WHITE-MATTER MICROSTRUCTURE; HEAD IMPACTS; DIFFUSIVITY MEASURES; ONE SEASON; CONTACT; CONCUSSION; INTEGRITY; INJURY; EXPOSURE;
D O I
10.1212/WNL.0000000000009821
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective To longitudinally assess brain microstructure and function in female varsity athletes participating in contact and noncontact sports. Methods Concussion-free female rugby players (n = 73) were compared to age-matched (ages 18-23) female swimmers and rowers (n = 31) during the in- and off-season. Diffusion and resting-state fMRI (rs-fMRI) measures were the primary outcomes. The Sports Concussion Assessment Tool and head impact accelerometers were used to monitor symptoms and impacts, respectively. Results We found cross-sectional (contact vs noncontact) and longitudinal (in- vs off-season) changes in white matter diffusion measures and rs-fMRI network connectivity in concussion-free contact athletes relative to noncontact athletes. In particular, mean, axial, and radial diffusivities were increased with decreased fractional anisotropy in multiple white matter tracts of contact athletes accompanied with default mode and visual network hyperconnectivity (p < 0.001). Longitudinal diffusion changes in the brainstem between the in- and off-season were observed for concussion-free contact athletes only, with progressive changes observed in a subset of athletes over multiple seasons. Axial diffusivity was significantly lower in the genu and splenium of the corpus callosum in those contact athletes with a history of concussion. Conclusions Together, these findings demonstrate longitudinal changes in the microstructure and function of the brain in otherwise healthy, asymptomatic athletes participating in contact sport. Further research to understand the long-term brain health and biological implications of these changes is required, in particular to what extent these changes reflect compensatory, reparative, or degenerative processes.
引用
收藏
页码:E402 / E412
页数:11
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