Immunological basis in the pathogenesis of intrahepatic cholestasis of pregnancy

被引：58
作者：
Larson, Spencer P. [1 ,2 ]
Kovilam, Oormila [2 ]
Agrawal, Devendra K. [1 ]
机构：
[1] Creighton Univ, Sch Med, Ctr Clin & Translat Sci, Omaha, NE 68178 USA
[2] Creighton Univ, Sch Med, Dept Obstet & Gynecol, Omaha, NE USA
来源：
EXPERT REVIEW OF CLINICAL IMMUNOLOGY | 2016年 / 12卷 / 01期
基金：
美国国家卫生研究院;
关键词：
intrahepatic cholestasis of pregnancy; bile acids; S-adenosylmethionine; T-lymphocytes; ursodeoxycholic acid; FARNESOID X RECEPTOR; URSODEOXYCHOLIC ACID TREATMENT; INCREASED SERUM-LEVELS; MATERNAL CHOLESTASIS; PROGESTERONE METABOLITES; INDUCED APOPTOSIS; OXIDATIVE STRESS; KAPPA-B; LIVER; CELLS;
D O I：
10.1586/1744666X.2016.1101344
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Intrahepatic cholestasis of pregnancy poses a great risk to both maternal and fetal health. Despite extensive research, much of the pathogenesis of this disorder is unknown. The increase in bile acids observed in patients with intrahepatic cholestasis of pregnancy has been noted to cause a change in the immune system from the normally mediated TH2 response to one that is more oriented towards TH1. In this literature review, we have critically reviewed the current literature regarding the changes in the immune system and the potential effects of immunological changes in the management of the patient. The current treatment, ursodeoxycholic acid, is also discussed along with potential combination therapies and future directions for research.
引用
收藏
页码：39 / 48
页数：10
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