Is N-acetyl cysteine protective against monocrotaline-induced toxicity?

被引：2

作者：

Karagoz, Serife ^{[1
]}

Ilgin, Sinem ^{[1
]}

Atli, Ozlem ^{[1
]}

Perk, Basak Ozlem ^{[1
]}

Burukoglu, Dilek ^{[2
]}

Ergun, Bulent ^{[1
]}

Sirmagul, Basar ^{[3
]}

机构：

[1] Anadolu Univ, Dept Pharmaceut Toxicol, Fac Pharm, TR-26470 Eskisehir, Turkey

[2] Osmangazi Univ, Fac Med, Dept Histol, Eskisehir, Turkey

[3] Osmangazi Univ, Fac Med, Dept Pharmacol, Eskisehir, Turkey

来源：

TOXIN REVIEWS | 2013年 / 32卷 / 03期

关键词：

Glutathione; hepatotoxicity; monocrotaline; N-acetyl cysteine; pulmonary toxicity; INDUCED PULMONARY-HYPERTENSION; ACETAMINOPHEN-INDUCED HEPATOTOXICITY; HEPATIC VENOOCCLUSIVE DISEASE; ENDOTHELIAL-CELL INJURY; PYRROLIZIDINE ALKALOIDS; LIVER INFLAMMATION; LIPID-PEROXIDATION; OXIDATIVE DAMAGE; RAT MODEL; ACETYLCYSTEINE;

D O I：

10.3109/15569543.2013.809547

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Monocrotaline (MCT) is a pyrrolizidine alkaloid which induces cardio-pulmonary toxicity and hepatotoxicity in animals and humans. MCT is frequently ingested because of food grain contamination accidentally or in the form of herbal medicine preparations. The aim of this study was to observe the protective effect of N-acetyl cysteine (NAC) on MCT-induced pulmonary toxicity and hepatotoxicity. According to our results (right ventricular pressures [RVPs], ratios of right ventricle (RV)/heart weight (HW), plasma AST levels, liver glutathione levels, liver MDA levels and liver histopathological examinations of groups), protective effects were observed with NAC treatment in both MCT-induced pulmonary toxicity and hepatotoxicity.

引用

页码：47 / 54

页数：8

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