Outcome in patients with isolated regional recurrence after primary radiotherapy for head and neck cancer

被引：9
作者：
Lindegaard, Anne Marie [1 ]
von Buchwald, Christian [2 ]
Rasmussen, Jacob H. [2 ]
Specht, Lena [1 ]
Vogelius, Ivan R. [1 ]
Zamani, Martin [2 ]
Woller, Nina Claire [3 ]
Lelkaitis, Giedrius [3 ]
Friborg, Jeppe [1 ]
机构：
[1] Univ Copenhagen, Rigshosp, Dept Oncol, Copenhagen, Denmark
[2] Univ Copenhagen, Rigshosp, Dept Otorhinolaryngol Head & Neck Surg & Audiol, Copenhagen, Denmark
[3] Univ Copenhagen, Rigshosp, Dept Pathol, Copenhagen, Denmark
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2020年 / 42卷 / 11期
关键词：
head and neck cancer; prognostic factors; recurrence; salvage treatment; survival; SQUAMOUS-CELL CARCINOMA; SALVAGE SURGERY; SURGICAL SALVAGE; EXTRACAPSULAR SPREAD; PROGNOSTIC-FACTORS; ELECTIVE NECK; OROPHARYNGEAL; CHEMOTHERAPY; IRRADIATION; SURVIVAL;
D O I：
10.1002/hed.26361
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Background Isolated regional recurrences following head-neck squamous-cell carcinomas (HNSCC) are often accessible for curatively intended salvage treatment. Factors prognostic for outcome were investigated in a large cohort of HNSCC patients. Methods In total, 1811 patients receiving curatively intended radiotherapy from 2007 to 2017 were reviewed and isolated cervical nodal recurrences were identified. Factors associated with survival and second recurrence were investigated using univariate and multivariate analyses. Results Isolated regional recurrence was seen in 95/1811 (5.2%) patients. Eighty of 95 patients (84%) received salvage surgery. Two-year survival after isolated regional recurrence was 40%. Overall survival (OS) and time to second recurrence were associated with resection status of the salvage surgery and presence of extranodal spread (ENS), while p16-positive oropharyngeal squamous-cell carcinoma (OPSCC) was associated with better OS. Conclusion Long-term survival after regional recurrence in HNSCC is possible. p16-positive OPSCC, complete salvage surgery, and lack of ENS are associated with better outcome.
引用
收藏
页码：3161 / 3170
页数：10
相关论文
共 39 条
[1]   Prognostic factors in salvage surgery for recurrent oral and oropharyngeal cancer [J].
Agra, IMG ;
Carvalho, AL ;
Ulbrich, FS ;
de Campos, OD ;
Martins, EP ;
Magrin, J ;
Kowalski, LP .
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2006, 28 (02) :107-113
[2]  
[Anonymous], 2009, UICC INT UNION CANC
[3]   Prognostic factors and long-term survivorship in patients with recurrent or metastatic carcinoma of the head and neck - An analysis of two Eastern Cooperative Oncology Group randomized trials [J].
Argiris, A ;
Li, Y ;
Forastiere, A .
CANCER, 2004, 101 (10) :2222-2229
[4]   Treatment of recurrent and advanced stage squamous cell carcinoma of the head and neck [J].
Arnold, DJ ;
Goodwin, WJ ;
Weed, DT ;
Civantos, FJ .
SEMINARS IN RADIATION ONCOLOGY, 2004, 14 (02) :190-195
[5]   REGIONAL OUTCOME IN OROPHARYNGEAL AND PHARYNGOLARYNGEAL CANCER TREATED WITH HIGH-DOSE PER FRACTION RADIOTHERAPY - ANALYSIS OF NECK DISEASE RESPONSE IN 1646 CASES [J].
BERNIER, J ;
BATAINI, JP .
RADIOTHERAPY AND ONCOLOGY, 1986, 6 (02) :87-103
[6]   Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): A comprehensive analysis by tumour site [J].
Blanchard, Pierre ;
Baujat, Bertrand ;
Holostenco, Victoria ;
Bourredjem, Abderrahmane ;
Baey, Charlotte ;
Bourhis, Jean ;
Pignon, Jean-Pierre .
RADIOTHERAPY AND ONCOLOGY, 2011, 100 (01) :33-40
[7]   Prognostic and predictive factors in recurrent and/or metastatic head and neck squamous cell carcinoma: A review of the literature [J].
Bossi, Paolo ;
Alfieri, Salvatore ;
Strojan, Primoz ;
Takes, Robert P. ;
Lopez, Fernando ;
Makitie, Antti ;
Saba, Nabil F. ;
Pablo Rodrigo, Juan ;
Bradford, Carol ;
Suarez, Carlos ;
Zafereo, Mark ;
Forastiere, Arlene A. ;
Vermorken, Jan B. ;
Quer, Miquel ;
Sanabria, Alvaro ;
Simo, Ricard ;
de Bree, Remco ;
Rinaldo, Alessandra ;
Ferlito, Alfio .
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2019, 137 :84-91
[8]   Data Set for the Reporting of Nodal Excisions and Neck Dissection Specimens for Head and Neck Tumors Explanations and Recommendations of the Guidelines From the International Collaboration on Cancer Reporting [J].
Bullock, Martin J. ;
Beitler, Jonathan, I ;
Carlson, Diane L. ;
Fonseca, Isabel ;
Hunt, Jennifer L. ;
Katabi, Nora ;
Sloan, Philip ;
Taylor, S. Mark ;
Williams, Michelle D. ;
Thompson, Lester D. R. .
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE, 2019, 143 (04) :452-462
[9]   Results of a Phase 2 Study Examining the Effects of Omitting Elective Neck Irradiation to Nodal Levels IV and Vb in Patients With N0-1 Nasopharyngeal Carcinoma [J].
Chen, Jian-zhou ;
Quynh-Thu Le ;
Han, Fei ;
Lu, Li-Xia ;
Huang, Shao-Min ;
Lin, Cheng-Guang ;
Deng, Xiao-Wu ;
Cui, Nian-Ji ;
Zhao, Chong .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2013, 85 (04) :929-934
[10]  
COX DR, 1972, J R STAT SOC B, V34, P187
1234