Molecular diversity of sphingolipid signalling

被引：72

作者：

Heringdorf, DMZ ^{[1
]}

vanKoppen, CJ ^{[1
]}

Jakobs, KH ^{[1
]}

机构：

[1] UNIV ESSEN GESAMTHSCH,INST PHARMAKOL,D-45122 ESSEN,GERMANY

来源：

FEBS LETTERS | 1997年 / 410卷 / 01期

关键词：

sphingolipid; sphingosine; 1-phosphate; sphingosylphosphorylcholine; G protein-coupled receptor; signal transduction;

D O I：

10.1016/S0014-5793(97)00320-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sphingolipid breakdown products are now being recognized to play a dual role in cellular signalling, acting as intracellular as well as extracellular signalling molecules. Both types of action may even be found with one sphingolipid species. The recent demonstration of G protein-coupled receptors with high affinity for sphingosine 1-phosphate and sphingosylphosphorylcholine has been followed by the discovery of several novel sphingolipid actions, such as regulation of heart rate, oxidative burst, neurite retraction or platelet activation. Ligand profiles and concentration-response relationships suggest the existence of putative sphingolipid receptor subtypes. Against this background, several observations on supposed sphingolipid second messenger actions deserve a new evaluation. (C) 1997 Federation of European Biochemical Societies.

引用

页码：34 / 38

页数：5

共 57 条

[31] Involvement of pertussis toxin-sensitive GTP-binding proteins in sphingosine 1-phosphate-induced activation of phospholipase C-Ca2+ system in HL60 leukemia cells [J].

Okajima, F ;

Tomura, H ;

Sho, K ;

Nochi, H ;

Tamoto, K ;

Kondo, Y .

FEBS LETTERS, 1996, 379 (03) :260-264

[32] PERTUSSIS TOXIN INHIBITS PHOSPHOLIPASE-C ACTIVATION AND CA2+ MOBILIZATION BY SPHINGOSYLPHOSPHORYLCHOLINE AND GALACTOSYLSPHINGOSINE IN HL-60 LEUKEMIA-CELLS - IMPLICATIONS OF GTP-BINDING PROTEIN-COUPLED RECEPTORS FOR LYSOSPHINGOLIPIDS [J].

OKAJIMA, F ;

KONDO, Y .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (44) :26332-26340

[33] SPHINGOSINE-1-PHOSPHATE AS 2ND MESSENGER IN CELL-PROLIFERATION INDUCED BY PDGF AND FCS MITOGENS [J].

OLIVERA, A ;

SPIEGEL, S .

NATURE, 1993, 365 (6446) :557-560

[34] Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: Action through a specific cell surface receptor [J].

Postma, FR ;

Jalink, K ;

Hengeveld, T ;

Moolenaar, WH .

EMBO JOURNAL, 1996, 15 (10) :2388-2392

[35] Sphingomyelin-derived lipids differentially regulate the extracellular signal-regulated kinase 2 (ERK-2) and c-Jun N-terminal kinase (JNK) signal cascades in airway smooth muscle [J].

Pyne, S ;

Chapman, J ;

Steele, L ;

Pyne, NJ .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1996, 237 (03) :819-826

[36] The differential regulation of cyclic AMP by sphingomyelin-derived lipids and the modulation of sphingolipid-stimulated extracellular signal regulated kinase-2 in airway smooth muscle [J].

Pyne, S ;

Pyne, NJ .

BIOCHEMICAL JOURNAL, 1996, 315 :917-923

[37] SPHINGOSINE 1-PHOSPHATE, A SPECIFIC ENDOGENOUS SIGNALING MOLECULE CONTROLLING CELL MOTILITY AND TUMOR-CELL INVASIVENESS [J].

SADAHIRA, Y ;

RUAN, FQ ;

HAKOMORI, SI ;

IGARASHI, Y .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (20) :9686-9690

[38] SPHINGOSINE-1-PHOSPHATE INHIBITS EXTRACELLULAR-MATRIX PROTEIN-INDUCED HAPTOTACTIC MOTILITY BUT NOT ADHESION OF B16 MOUSE MELANOMA-CELLS [J].

SADAHIRA, Y ;

ZHENG, MZ ;

RUAN, FQ ;

HAKOMORI, SI ;

IGARASHI, Y .

FEBS LETTERS, 1994, 340 (1-2) :99-103

[39] SPHINGOSYLPHOSPHORYLCHOLINE ACTIVATION OF MITOGEN-ACTIVATED PROTEIN-KINASE IN SWISS 3T3 CELLS REQUIRES PROTEIN-KINASE-C AND A PERTUSSIS-TOXIN-SENSITIVE G-PROTEIN [J].

SEUFFERLEIN, T ;

ROZENGURT, E .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (41) :24334-24342

[40]

SPIEGEL S, 1993, ADV LIPID RES, V25, P105

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