Effects of molybdenum on sperm quality and testis oxidative stress

被引：38

作者：

Zhai, Xiao-Wei ^{[1
]}

Zhang, Yu-Ling ^{[1
]}

Qi, Qiao ^{[1
]}

Bai, Yu ^{[1
]}

Chen, Xiao-Li ^{[1
]}

Jin, Li-Jun ^{[1
]}

Ma, Xue-Gang ^{[1
]}

Shu, Run-Zhe ^{[2
]}

Yang, Zi-Jun ^{[1
]}

Liu, Feng-Jun ^{[1
]}

机构：

[1] Henan Univ Sci & Technol, Coll Anim Sci & Technol, Luoyang 471003, Peoples R China

[2] Monash Univ, Monash Immunol & Stem Cell Labs, Clayton, Vic, Australia

来源：

SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE | 2013年 / 59卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Molybdenum; mouse; oxidative stress; sperm parameters; testis; TRACE-ELEMENTS; EXPOSURE; GENERATION; FERTILITY; CADMIUM; METALS; DAMAGE; SEMEN;

D O I：

10.3109/19396368.2013.791347

中图分类号：

R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

摘要：

In order to investigate the effects of molybdenum (Mo) on sperm parameters and testicular oxidative stress, the ICR strain of adult mice were exposed to different doses of molybdenum for a sub-acute toxicity test. Compared to the control, our results showed that the sperm parameters, including the epididymis index, sperm motility, sperm count, and morphology, increased by a moderate dose of Mo (25 mg/L), but were negatively affected at high doses (>= 100 mg/L). In addition, the changes of sperm parameters were accompanied with changes of the superoxide dismutase (SOD) activities, the glutathione peroxidase (GPx) activities, and the malondialdehyde (MDA) levels in testes. In conclusion, Mo affects the sperm quality through regulating the testicular oxidative stress in a complex manner.

引用

页码：251 / 255

页数：5

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