Chromatographic separation and analysis of chlorpheniramine maleate, methscopolamine nitrate and phenylephrine hydrochloride in sustained release capsules

被引：13
作者：
Metwally, MES [1 ]
机构：
[1] Univ Mansoura, Fac Pharm, Dept Analyt Chem, El Mansoura 35516, Egypt
来源：
CHROMATOGRAPHIA | 1999年 / 50卷 / 1-2期
关键词：
column liquid chromatography; chlorpheniramine; phenylephrine; methscopolamine; sustained release capsules;
D O I：
10.1007/BF02493628
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A high performance liquid chromatographic method has bee developed for the simultaneous determination of chlorpheniramine maleate (CPM), methscoplamine nitrate (MSN) and phenylephrine hydrochloride (PEH) in sustained release capsules. the separation was carried out on a reverse-phase CN-column with use of a mobile phase consisting of 70% (v/v) solution of acetonitrile in water containing 2% (v/v) acetic acid and 0.005M sodium 1-heptane sulfonate at a flow rate of 2 mL min(-1). The eluted peaks were detected at 262 nm. The method is sensitive, accurate and rapid and can be used in the routine analysis of the mixture of the three compounds.
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页码：113 / 117
页数：5
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