Dual Responsive, Stabilized Nanoparticles for Efficient In Vivo Plasmid Delivery

被引：109

作者：

Wei, Hua ^{[1
,2
]}

Volpatti, Lisa R. ^{[1
,2
]}

Sellers, Drew L. ^{[3
]}

Maris, Don O. ^{[3
]}

Andrews, Ian W. ^{[1
,2
]}

Hemphill, Ashton S. ^{[1
,2
]}

Chan, Leslie W. ^{[1
,2
]}

Chu, David S. H. ^{[1
,2
]}

Horner, Philip J. ^{[3
]}

Pun, Suzie H. ^{[1
,2
]}

机构：

[1] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

[2] Univ Washington, Mol Engn & Sci Inst, Seattle, WA 98195 USA

[3] Univ Washington, Dept Neurol Surg, Seattle, WA 98195 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 20期

关键词：

copolymers; DNA nanoparticles; gene transfection; hydrophobization; hydrophilization; BLOCK-COPOLYMER MICELLES; PCL-B-PEG; GENE DELIVERY; SIRNA; CELLS; VITRO; DNA; POLYMERIZATION; NANOCARRIERS; THERAPY;

D O I：

10.1002/anie.201301896

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A small case of love and hate: A block-statistical copolymer combining reversible hydrophobization and statistical hydrophilization allows the preparation of pH value- and reduction-responsive nanoparticles (polyplexes) for efficient in vivo plasmid delivery. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：5377 / 5381

页数：5

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