Plasmacytoid dendritic cells and interferon levels are increased in lymphatic malformations

被引：9

作者：

Fleming, Jo Nadine ^{[2
]}

Hostikka, Sirkka Liisa ^{[2
]}

Chen, Eunice Y.

Schwartz, Stephen M. ^{[2
]}

Perkins, Jonathan A. ^{[1
]}

机构：

[1] Childrens Hosp & Med Ctr, Div Otolaryngol Head & Neck Surg, Dept Pediat Otolaryngol, Seattle, WA 98105 USA

[2] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

来源：

OTOLARYNGOLOGY-HEAD AND NECK SURGERY | 2008年 / 139卷 / 05期

关键词：

D O I：

10.1016/j.otohns.2008.07.032

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

OBJECTIVE: Describe the presence of plasmacytoid dendritic cells and type 1 interferon and the activation of interferon signaling pathway in lymphatic malformations. DESIGN: Retrospective case series. MATERIALS: Nineteen lymphatic malformations with matching clinical data were compared to control tissue (normal skin and lymph node). METHODS: Paraffin-embedded tissue was evaluated for plasmacytoid dendritic cells, type 1 interferon, and type 1 interferon signaling with inmumohistochemistry and RNA in situ hybridization. Staining results were compared with controls and correlated with clinical data with descriptive statistics and Mann-Whitney tests. RESULTS: Lymphatic malformations had increased staining for plasmacytoid dendritic cells, interferons alpha and beta, and phosphorylated signal transducer and activator of transcription 1 compared with controls (P < 0.05). Significantly increased interferon beta staining was present in recurrent lymphatic malformation tissue compared with nonrecurrent lymphatic malformations. CONCLUSION: Lymphatic malformations have unusual ongoing local immune activation, possibly affecting recurrence. (C) 2008 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved.

引用

页码：671 / 676

页数：6

共 20 条

[11]

Lee B B, 2005, Vasc Endovascular Surg, V39, P67, DOI 10.1177/153857440503900107

[12] Type I interferons produced by dendritic cells promote their phenotypic and functional activation [J].

Montoya, M ;

Schiavoni, G ;

Mattei, F ;

Gresser, I ;

Belardelli, F ;

Borrow, P ;

Tough, DF .

BLOOD, 2002, 99 (09) :3263-3271

[13]

Mulliken JB, 2000, CURR PROB SURG, V37, P521

[14]

RICCIARDELLI EJ, 1991, ARCH OTOLARYNGOL, V117, P546

[15] The relaxation dynamics of a simple glass former confined in a pore [J].

Scheidler, P ;

Kob, W ;

Binder, K .

EUROPHYSICS LETTERS, 2000, 52 (03) :277-283

[16] Influence of IFN-α and IFN-γ on lymphangiogenesis [J].

Shao, Xujian ;

Liu, Chao .

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2006, 26 (08) :568-574

[17] How cells respond to interferons [J].

Stark, GR ;

Kerr, IM ;

Williams, BRG ;

Silverman, RH ;

Schreiber, RD .

ANNUAL REVIEW OF BIOCHEMISTRY, 1998, 67 :227-264

[18] The interferon-α/β system in antiviral responses:: a multimodal machinery of gene regulation by the IRF family of transcription factors [J].

Taniguchi, T ;

Takaoka, A .

CURRENT OPINION IN IMMUNOLOGY, 2002, 14 (01) :111-116

[19] Lymphocytopenia in children with lymphatic malformation [J].

Tempero, RM ;

Hannibal, M ;

Finn, LS ;

Manning, SC ;

Cunningham, ML ;

Perkins, JA .

ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, 2006, 132 (01) :93-97

[20] Effects of interferon alpha on vascular endothelial growth factor gene transcription and tumor angiogenesis [J].

von Marschall, Z ;

Scholz, A ;

Cramer, T ;

Schäfer, G ;

Schirner, M ;

Öberg, K ;

Wiedenmann, B ;

Höcker, M ;

Rosewicz, S .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2003, 95 (06) :437-448

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