Tissue specificity of cardiac troponin I, cardiac troponin T and creatine kinase-MB

被引：105

作者：

Apple, FS ^{[1
]}

机构：

[1] Univ Minnesota, Sch Med, Hennepin Cty Med Ctr, Clin Labs,Dept Lab Med & Pathol, Minneapolis, MN 55415 USA

来源：

CLINICA CHIMICA ACTA | 1999年 / 284卷 / 02期

关键词：

tissue specificity; human skeletal muscle; heart; creatine kinase-MB; cardiac troponin;

D O I：

10.1016/S0009-8981(99)00077-7

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The purpose of the paper is to review the tissue specificity of creatine kinase (CK)-MB, cardiac troponin I (cTnI), and cardiac troponin T (cTnT) in human and animal heart and skeletal muscle. Alterations are described which demonstrate that CK-MB is expressed in human skeletal muscle, and is not 100% specific for the heart, cTnI has been shown to be 100% specific for the heart. While cTnT isoforms are expressed in injured skeletal muscle, they are not detected by the diagnostic assays used in clinical practice. Therefore, cTnI or cTnT challenge CK-MB as the new standards for detection of myocardial injury. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：151 / 159

页数：9

共 24 条

[1] CARDIAC TROPONIN-I - A MARKER WITH HIGH SPECIFICITY FOR CARDIAC INJURY [J].