Malaria in infants aged less than six months - is it an area of unmet medical need?

被引：56

作者：

D'Alessandro, Umberto ^{[1
,2
]}

Ubben, David ^{[3
]}

Hamed, Kamal ^{[4
]}

Ceesay, Serign Jawo ^{[1
]}

Okebe, Joseph ^{[1
]}

Taal, Makie ^{[5
]}

Lama, Eugene Kaman ^{[6
]}

Keita, Moussa ^{[6
]}

Koivogui, Lamine ^{[6
]}

Nahum, Alain ^{[7
]}

Bojang, Kalifa ^{[1
]}

Sonko, Aja Adam Jagne ^{[5
]}

Lalya, Honorat Francis ^{[8
]}

Brabin, Bernard ^{[9
]}

机构：

[1] MRC Unit, Banjul, Gambia

[2] Inst Trop Med, B-2000 Antwerp, Belgium

[3] MMV, CH-1215 Geneva 15, Switzerland

[4] Novartis Pharmaceut, E Hanover, NJ 07936 USA

[5] Minist Hlth & Social Welf, Banjul, Gambia

[6] Minist Hlth, Conakry, Guinea

[7] Ctr Rech Entomol Cotonou, Cotonou, Benin

[8] Ctr Natl Hosp Univ Hubert K Maga, Cotonou, Benin

[9] Univ Liverpool, Liverpool Sch Trop Med, Child & Reprod Hlth Grp, Liverpool L3 5QA, Merseyside, England

来源：

MALARIA JOURNAL | 2012年 / 11卷

关键词：

Malaria; Neonate; Congenital; Prevalence; Parasitaemia; Artemisinin-based combination therapy; PLASMODIUM-FALCIPARUM MALARIA; SUB-SAHARAN AFRICA; CONGENITAL MALARIA; CHILDREN; MORTALITY; DISTRICT; INFECTIONS; PREVALENCE; PREGNANCY; PATTERNS;

D O I：

10.1186/1475-2875-11-400

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Despite the protection provided by several factors, including maternal antibodies, the burden of malaria in young infants may be higher than previously thought. Infants with congenital or neonatal malaria may have a different clinical presentation than older children, and diagnosis may be confused with other neonatal diseases due to an overlap of clinical manifestations. In addition, there is little information on the use of artemisinin-based combination therapy in young infants. There is the need for a more accurate estimate of the parasite prevalence and the incidence of clinical malaria in infants under 6 months old, as well as a better characterization of risk factors, pharmacokinetic profiles, safety and efficacy of currently available anti-malarial treatments, in order to develop evidence-based treatment guidelines for this population.

引用

页数：6

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