Selected polymorphisms in sex hormone-related genes, circulating sex hormones and risk of endometrial cancer

被引：31

作者：

Lundin, Eva ^{[2
]}

Wirgin, Isaac

Lukanova, Annekatrin ^{[3
,4
]}

Afanasyeva, Yelena

Krogh, Vittorio ^{[5
]}

Axelsson, Tomas ^{[6
]}

Hemminki, Kari ^{[7
,8
,9
]}

Clendenen, Tess V.

Arslan, Alan A. ^{[4
,10
]}

Ohlson, Nina ^{[2
]}

Sieri, Sabina ^{[5
]}

Roy, Nirmal

Koenig, Karen L.

Idahl, Annika ^{[11
]}

Berrino, Franco ^{[12
]}

Toniolo, Paolo ^{[4
,13
]}

Hallmans, Goran ^{[14
]}

Foersti, Asta ^{[8
,9
]}

Muti, Paola ^{[15
,16
]}

Lenner, Per ^{[17
]}

Shore, Roy E. ^{[18
]}

Zeleniuch-Jacquotte, Anne ^{[1
,10
]}

机构：

[1] NYU, Sch Med, Div Epidemiol, Dept Environm Med, New York, NY 10016 USA

[2] Umea Univ, Dept Med Biosci, Umea, Sweden

[3] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[4] NYU, Sch Med, Dept Obstet & Gynecol, New York, NY 10016 USA

[5] Natl Canc Inst, Nutr Epidemiol Unit, I-20133 Milan, Italy

[6] Uppsala Univ, Dept Med Sci, Uppsala, Sweden

[7] Karolinska Inst, Novum, Dept Biosci, Huddinge, Sweden

[8] German Canc Res Ctr, Div Mol Genet Epidemiol, Heidelberg, Germany

[9] Lund Univ, Clin Res Ctr, Ctr Primary Hlth Care Res, Malmo, Sweden

[10] NYU, Sch Med, Inst Canc, New York, NY 10016 USA

[11] Umea Univ, Dept Clin Sci Obstet & Gynecol, Umea, Sweden

[12] Natl Canc Inst, Etiol & Prevent Epidemiol Unit, I-20133 Milan, Italy

[13] CHU Vaudois, Inst Social & Prevent Med, Lausanne, Switzerland

[14] Umea Univ, Dept Publ Hlth & Clin Med Nutr Res, Umea, Sweden

[15] McMaster Univ, Dept Oncol, Dofasco Chair Canc Expt Therapeut, Hamilton, ON, Canada

[16] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[17] Univ Umea Hosp, Dept Oncol, S-90185 Umea, Sweden

[18] Radiat Effects Res Fdn, Hiroshima, Japan

来源：

CANCER EPIDEMIOLOGY | 2012年 / 36卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Endometrial cancer; Estrogen; Sex hormone-binding globulin; Progesterone receptor; Single nucleotide polymorphism; PROGESTERONE-RECEPTOR GENE; SINGLE-NUCLEOTIDE POLYMORPHISMS; BINDING GLOBULIN SHBG; BREAST-CANCER; POSTMENOPAUSAL WOMEN; FUNCTIONAL POLYMORPHISM; PROGINS POLYMORPHISM; ENDOGENOUS ESTROGENS; REPLACEMENT THERAPY; CYTOCHROME P4501B1;

D O I：

10.1016/j.canep.2012.04.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: The role of estrogen and progesterone in the development of endometrial cancer is well documented. Few studies have examined the association of genetic variants in sex hormone-related genes with endometrial cancer risk. Methods: We conducted a case-control study nested within three cohorts to examine the association of endometrial cancer risk with polymorphisms in hormone-related genes among 391 cases (92% postmenopausal at diagnosis) and 712 individually-matched controls. We also examined the association of these polymorphisms with circulating levels of sex hormones and SHBG in a cross-sectional analysis including 596 healthy postmenopausal women at blood donation (controls from this nested case-control study and from a nested case-control study of breast cancer in one of the three cohorts). Results: Adjusting for endometrial cancer risk factors, the A allele of rs4775936 in CYP19 was significantly associated (ORper allele = 1.22, 95% CI = 1.01-1.47, p(trend) = 0.04), while the T allele of rs10046 was marginally associated with increased risk of endometrial cancer (ORper allele = 1.20, 95% CI = 0.99-1.45, p(trend) = 0.06). PGR rs1042838 was also marginally associated with risk (ORper allele = 1.25, 95% CI = 0.96-1.61, p(trend) = 0.09). No significant association was found for the other polymorphisms, i.e. CYP1B1 rs1800440 and rs1056836, UGT1A1 rs8175347, SHBG rs6259 and ESR1 rs2234693. Rs8175347 was significantly associated with postmenopausal levels of estradiol, free estradiol and estrone and rs6259 with SHBG and estradiol. Conclusion: Our findings support an association between genetic variants in CYP19, and possibly PGR, and risk of endometrial cancer. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：445 / 452

页数：8

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