Detection of cancer-specific epigenomic changes in biofluids: Powerful tools in biomarker discovery and application

被引：17

作者：

da Costa, Andre Nogueira ^{[1
]}

Herceg, Zdenko ^{[1
]}

机构：

[1] Int Agcy Res Canc, Epigenet Grp, F-69372 Lyon 08, France

来源：

MOLECULAR ONCOLOGY | 2012年 / 6卷 / 06期

关键词：

Biomarkers; DNA methylation; Body fluids; Early cancer detection; Epigenomics; ABERRANT DNA METHYLATION; GENE-PROMOTER HYPERMETHYLATION; CIRCULATING FREE DNA; K-RAS MUTATIONS; LUNG-CANCER; HEPATOCELLULAR-CARCINOMA; QUANTITATIVE-ANALYSIS; CELL-FREE; SERUM DNA; PLASMA DNA;

D O I：

10.1016/j.molonc.2012.07.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The genetic and epigenetic material originating from tumour that can be found in body fluids of individuals with cancer harbours tumour-specific alterations and represents an attractive target for biomarker discovery. Epigenetic changes (DNA methylation, histone modifications and non-coding RNAs) are present ubiquitously in virtually all types of human malignancies and may appear in early cancer development, and thus they provide particularly attractive markers with broad applications in diagnostics. In addition, because changes in the epigenome may constitute a signature of specific exposure to certain risk factors, they have the potential to serve as highly specific biomarkers for risk assessment. While reliable detection of cancer-specific epigenetic changes has proven to be technically challenging, a substantial progress has been made in developing the methodologies that allow an efficient and sensitive detection of epigenomic changes using the material originating from body fluids. In this review we discuss the application of epigenomics as a tool for biomarker research, with the focus on the analysis of DNA methylation in biofluids. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：704 / 715

页数：12

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