Genetic Screening in Infertile Mexican Men: Chromosomal Abnormalities, Y Chromosome Deletions, and Androgen Receptor CAG Repeat Length

被引：21
|
作者：
Guadalupe Martinez-Garza, Sandra [1 ]
Celina Gallegos-Rivas, Mayra [1 ]
Vargas-Maciel, Marcos [1 ]
Manuel Rubio-Rubio, Juan [1 ]
Espinosa de los Monteros-Rodriguez, Mario [1 ]
Gonzalez-Ortega, Claudia [1 ]
Cancino-Villarreal, Patricia [1 ]
Vazquez de Lara, Luis G. [2 ]
Martin Gutierrez-Gutierrez, Antonio [1 ]
机构：
[1] Inst Ciencias Reprod Humana Vida Inst Vida, Guanajuato 37160, Mexico
[2] Benemerita Univ Autonoma Puebla, Fac Med, Puebla, Mexico
来源：
JOURNAL OF ANDROLOGY | 2008年 / 29卷 / 06期
关键词：
Oligospermia; karyotype; microdeletion; trinucleotide repeat;
D O I：
10.2164/jandrol.107.004309
中图分类号：
R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
摘要：
In our study, we analyzed chromosomal abnormalities, Y chromosome deletions, androgen receptor CAG repeat length and their association with defective spermatogenesis in infertile Mexican men. Eighty-two infertile patients and 40 controls were screened for karyotypic abnormalities, Y chromosome microdeletions, and CAG repeats. Nine infertile males (11%) carried chromosomal abnormalities and 10 (12.2%) presented Y chromosome microdeletions. The mean CAG repeat length was 21.6 and 20.88 base pairs in idiopathic infertile males and controls, respectively. Our results suggest that chromosomal aberrations and Y-chromosomal microdeletions are related to male infertility in Mexican men. In addition, expansion of the CAG repeat segments of the androgen receptor is not correlated with male idiopathic infertility.
引用
收藏
页码：654 / 660
页数：7
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