Genetic Screening in Infertile Mexican Men: Chromosomal Abnormalities, Y Chromosome Deletions, and Androgen Receptor CAG Repeat Length

被引：21

作者：

Guadalupe Martinez-Garza, Sandra ^{[1
]}

Celina Gallegos-Rivas, Mayra ^{[1
]}

Vargas-Maciel, Marcos ^{[1
]}

Manuel Rubio-Rubio, Juan ^{[1
]}

Espinosa de los Monteros-Rodriguez, Mario ^{[1
]}

Gonzalez-Ortega, Claudia ^{[1
]}

Cancino-Villarreal, Patricia ^{[1
]}

Vazquez de Lara, Luis G. ^{[2
]}

Martin Gutierrez-Gutierrez, Antonio ^{[1
]}

机构：

[1] Inst Ciencias Reprod Humana Vida Inst Vida, Guanajuato 37160, Mexico

[2] Benemerita Univ Autonoma Puebla, Fac Med, Puebla, Mexico

来源：

JOURNAL OF ANDROLOGY | 2008年 / 29卷 / 06期

关键词：

Oligospermia; karyotype; microdeletion; trinucleotide repeat;

D O I：

10.2164/jandrol.107.004309

中图分类号：

R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

摘要：

In our study, we analyzed chromosomal abnormalities, Y chromosome deletions, androgen receptor CAG repeat length and their association with defective spermatogenesis in infertile Mexican men. Eighty-two infertile patients and 40 controls were screened for karyotypic abnormalities, Y chromosome microdeletions, and CAG repeats. Nine infertile males (11%) carried chromosomal abnormalities and 10 (12.2%) presented Y chromosome microdeletions. The mean CAG repeat length was 21.6 and 20.88 base pairs in idiopathic infertile males and controls, respectively. Our results suggest that chromosomal aberrations and Y-chromosomal microdeletions are related to male infertility in Mexican men. In addition, expansion of the CAG repeat segments of the androgen receptor is not correlated with male idiopathic infertility.

引用

页码：654 / 660

页数：7

共 50 条

[21] Frequency of Y chromosome microdeletions and chromosomal abnormalities in infertile Thai men with oligozoospermia and azoospermia
Vutyavanich, Teraporn
Piromlertamorn, Waraporn
Sirirungsi, Wasna
Sirisukkasem, Supachai
ASIAN JOURNAL OF ANDROLOGY, 2007, 9 (01) : 68 - 75
[22] Y chromosome microdeletions and chromosomal abnormalities in infertile saudi men with idiopathic oligo - or azoospermia
Al-Hassan, S.
Hellani, A.
Coskun, S.
INTERNATIONAL JOURNAL OF ANDROLOGY, 2005, 28 : 93 - 93
[23] Effect of smoking on semen quality, FSH, testosterone level, and CAG repeat length in androgen receptor gene of infertile men in an Indian city
Mitra, Amrita
Chakraborty, Baidyanath
Mukhopadhay, Dyutiman
Pal, Manisha
Mukherjee, Sanjit
Banerjee, Samir
Chaudhuri, Keya
SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE, 2012, 58 (05) : 255 - 262
[24] Have androgen receptor gene CAG and GGC repeat polymorphisms an effect on sperm motility in infertile men?
Muti, N. Delli
Agarwal, A.
Buldreghini, E.
Gioia, A.
Lenzi, A.
Boscaro, M.
Balercia, G.
ANDROLOGIA, 2014, 46 (05) : 564 - 569
[25] Cytogenetic and molecular analysis of the Y chromosome: absence of a significant relationship between CAG repeat length in exon 1 of the androgen receptor gene and infertility in Indian men
Dhillon, VS
Husain, SA
INTERNATIONAL JOURNAL OF ANDROLOGY, 2003, 26 (05): : 286 - 295
[26] Androgen receptor CAG repeat length polymorphism modifies the impact of testosterone on insulin sensitivity in men
Moehlig, Matthias
Arafat, Ayman M.
Osterhoff, Martin A.
Isken, Frank
Weickert, Martin O.
Spranger, Joachim
Pfeiffer, Andreas F. H.
Schoefl, Christof
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2011, 164 (06) : 1013 - 1018
[27] Genetic screening for AZF Y chromosome microdeletions in Jordanian azoospermic infertile men
Khabour, Omar F.
Fararjeh, AbdulFattah S.
Alfaouri, Almuthana A.
INTERNATIONAL JOURNAL OF MOLECULAR EPIDEMIOLOGY AND GENETICS, 2014, 5 (01): : 47 - 50
[28] Expression of Humoral Autoimmunity is Related to Androgen Receptor CAG Repeat Length in Men with Systemic Lupus Erythematosus
Alex H. Tessnow
Nancy J. Olsen
William J. Kovacs
Journal of Clinical Immunology, 2011, 31
[29] Expression of Humoral Autoimmunity is Related to Androgen Receptor CAG Repeat Length in Men with Systemic Lupus Erythematosus
Tessnow, Alex H.
Olsen, Nancy J.
Kovacs, William J.
JOURNAL OF CLINICAL IMMUNOLOGY, 2011, 31 (04) : 567 - 573
[30] Association between androgen receptor gene CAG trinucleotide repeat length and testicular histology in older men
Dakoitane-Giudicelli, Mbarka
Legrand, Beatrice
Bergere, Marianne
Giudicelli, Yves
Cussenot, Olivier
Selva, Jacqueline
FERTILITY AND STERILITY, 2006, 86 (04) : 873 - 877

← 1 2 3 4 5 →