Antioxidative and anti-inflammatory effects of polyphenol-rich litchi (Litchi chinensis Sonn.)-flower-water-extract on livers of high-fat-diet fed hamsters

被引：40

作者：

Chang, Yuan-Yen ^{[1
,2
,3
]}

Yang, Deng-Jye ^{[4
]}

Chiu, Chih-Hsien ^{[5
]}

Lin, Yi-Ling ^{[6
]}

Chen, Jr-Wei ^{[7
]}

Chen, Yi-Chen ^{[5
,8
]}

机构：

[1] Chung Shan Med Univ, Sch Med, Dept Microbiol & Immunol, Taichung 402, Taiwan

[2] Chung Shan Med Univ, Inst Microbiol & Immunol, Taichung 402, Taiwan

[3] Chung Shan Med Univ Hosp, Clin Lab, Taichung 402, Taiwan

[4] Chung Shan Med Univ, Sch Hlth Diet & Ind Management, Taichung 402, Taiwan

[5] Natl Taiwan Univ, Dept Anim Sci & Technol, Taipei 106, Taiwan

[6] Chung Shan Med Univ, Inst Biochem & Biotechnol, Taichung 402, Taiwan

[7] Council Agr, Anim Ind Dept, Livestock Ind Div, Executive Yuan, Taiwan

[8] Natl Taiwan Univ, Zoonoses Res Ctr, Taipei 106, Taiwan

来源：

JOURNAL OF FUNCTIONAL FOODS | 2013年 / 5卷 / 01期

关键词：

Antioxidative capacity; Hepatic lipids; Litchi-flower-water-extract; Liver cytokine level; Liver damage index; Matrix metalloproteinase; Nonalcoholic fatty liver; Polyphenolic profile; OXIDATIVE STRESS; RATS; EXTRACT; DISEASE; ANTIOBESITY; CHOLESTEROL; PARAMETERS; FIBROSIS; DENSITY; FLOWERS;

D O I：

10.1016/j.jff.2012.08.002

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Gentisic acid and epicatechin are two major compounds in phenolic acids and flavonoids of litchi-flower-water extracts (LFWEs), respectively. Increased (p<0.05) serum lipids and liver size/lipid, damage/inflammatory indices, TBARS value, CRP level, MMP-9 activity, and decreased (p<0.05) liver GSH and TEAC levels, and SOD, CAT and GSH-Px activities were observed in high-fat-diet fed hamsters compared to normal-fat-dietary hamsters. Those biochemical values of high-fat-diet fed hamsters were significant improved (p<0.05) by drinking LFWEs. In addition, these improvements on liver damage induced by a high-fat diet were also evidenced in the histopathological examination of livers where less micro-vesicular steatosis and no necrotic/inflammatory cells were observed in high-fat-diet fed hamster drinking LFWEs. Therefore, protective effects of LFWEs on liver damage of high-fat-diet fed hamsters can be accounted for antioxidative properties and anti-inflammatory effects of LFWEs. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：44 / 52

页数：9

共 33 条

[1] Nonalcoholic fatty liver disease [J].

Adams, Leon A. ;

Lindor, Keith D. .

ANNALS OF EPIDEMIOLOGY, 2007, 17 (11) :863-869

[2] Gentisic acid, an aspirin metabolite, inhibits oxidation of low-density lipoprotein and the formation of cholesterol ester hydroperoxides in human plasma [J].

Ashidate, K ;

Kawamura, M ;

Mimura, D ;

Tohda, H ;

Miyazaki, S ;

Teramoto, T ;

Yamamoto, Y ;

Hirata, Y .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2005, 513 (03) :173-179

[3] Preventive Effects of Taurine on Development of Hepatic Steatosis Induced by a High-Fat/Cholesterol Dietary Habit [J].

Chang, Yuan-Yen ;

Chou, Chung-Hsi ;

Chiu, Chih-Hsien ;

Yang, Kuo-Tai ;

Lin, Yi-Ling ;

Weng, Wei-Lien ;

Chen, Yi-Chen .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2011, 59 (01) :450-457

[4] Hepatoprotection of silymarin against thioacetamide-induced chronic liver fibrosis [J].

Chen, I-Shu ;

Chen, Yi-Chen ;

Chou, Chung-Hsi ;

Chuang, Ruei-Feng ;

Sheen, Lee-Yan ;

Chiu, Chih-Hsien .

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 2012, 92 (07) :1441-1447

[5] Red mold rice prevents the development of obesity, dyslipidemia and hyperinsulinemia induced by high-fat diet [J].

Chen, W-P ;

Ho, B-Y ;

Lee, C-L ;

Lee, C-H ;

Pan, T-M .

INTERNATIONAL JOURNAL OF OBESITY, 2008, 32 (11) :1694-1704

[6] Effects of taurine on hepatic lipid metabolism and anti-inflammation in chronic alcohol-fed rats [J].

Chou, Chung-Hsi ;

Chang, Yuan-Yen ;

Tzang, Bor-Show ;

Hsu, Chin-Lin ;

Lin, Yi-Ling ;

Lin, Hui-Wen ;

Chen, Yi-Chen .

FOOD CHEMISTRY, 2012, 135 (01) :24-30

[7] Effect of fermentation on the antioxidant activity of red beans (Phaseolus radiatus L. var. Aurea) ethanolic extract [J].

Chou, Su-Tze ;

Chao, Wen-Wan ;

Chung, Yun-Chin .

INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 2008, 43 (08) :1371-1378

[8] Human Fatty Liver Disease: Old Questions and New Insights [J].

Cohen, Jonathan C. ;

Horton, Jay D. ;

Hobbs, Helen H. .

SCIENCE, 2011, 332 (6037) :1519-1523

[9] Oxidative stress in vascular disease:: causes, defense mechanisms and potential therapies [J].

Foerstermann, Ulrich .

NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE, 2008, 5 (06) :338-349

[10] Suppressive effect of a proanthocyanidin-rich extract from longan (Dimocarpus longan Lour.) flowers on nitric oxide production in LPS-stimulated macrophage cells [J].

Ho, Su-Chen ;

Hwang, Lucy Sun ;

Shen, Yi-Jane ;

Lin, Chih-Cheng .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2007, 55 (26) :10664-10670

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