Comorbid diseases of IgG4-related sialadenitis in the head and neck region

被引：19

作者：

Hong, Xia ^{[1
]}

Sun, Zhi-Peng ^{[2
]}

Li, Wei ^{[1
]}

Chen, Yan ^{[3
]}

Gao, Yan ^{[3
]}

Su, Jia-Zeng ^{[1
]}

Wang, Zhen ^{[1
]}

Cai, Zhi-Gang ^{[1
]}

Li, Tong-Tong ^{[1
]}

Zhang, Lei ^{[1
]}

Liu, Xiao-Jing ^{[1
]}

Liu, Yan-Ying ^{[4
]}

He, Jing ^{[4
]}

Li, Zhan-Guo ^{[4
]}

Yu, Guang-Yan ^{[1
]}

机构：

[1] Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China

[2] Peking Univ, Sch & Hosp Stomatol, Dept Oral Radiol, Beijing 100081, Peoples R China

[3] Peking Univ, Sch & Hosp Stomatol, Dept Oral Pathol, Beijing 100081, Peoples R China

[4] Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100081, Peoples R China

来源：

LARYNGOSCOPE | 2015年 / 125卷 / 09期

关键词：

IgG4-related sialadenitis; comorbid diseases; head and neck; rhinosinusitis; lymphadenopathy; ocular adnexa; salivary gland; IMMUNOGLOBULIN G4-RELATED DISEASE; AUTOIMMUNE PANCREATITIS; LYMPH-NODES; MANIFESTATIONS; LYMPHADENOPATHY; DACRYOADENITIS; RHINOSINUSITIS; ENLARGEMENT; PREVALENCE; LESIONS;

D O I：

10.1002/lary.25387

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Objectives/HypothesisTo further recognize the comorbid diseases of immunoglobulin G4-related sialadenitis (IgG4-RS) in the head and neck region and to observe the response of these conditions to immunomodulatory therapy. Study DesignRetrospective review. MethodsThe symptoms of comorbid diseases and medical histories in 51 patients (24 men, 27 women; median age, 55 years) diagnosed with IgG4-RS were analyzed. Thirty-six patients received immunomodulatory therapy and were followed up for 10.45.9 months. Computed tomography (CT) examination was performed before and after therapy. ResultsRhinosinusitis occurred in 58.8% patients, and manifested with the symptoms of nasal obstruction, nasal xerosis, and hyposmia. In addition, 43.1% patients had allergic rhinitis. Lymphadenopathy was identified in 74.5% patients. Lacrimal gland swelling occurred in 78.4% patients. Extraocular muscles, otologic organs, skin and superficial soft tissue, and cranial nerves were also involved. All of the lesions were relieved after immunomodulatory therapy. The Lund-Mackay scores decreased (9.65.6 to 1.0 +/- 2.2) according to CT analyses (P<.05). Mean CT volumes of the swollen lymph nodes and lacrimal glands decreased from 1.21 +/- 0.61 cm(3) to 0.59 +/- 0.35 cm(3) and from 2.25 +/- 1.35 cm(3) to 0.70 +/- 0.32 cm(3), respectively (P < .05) after treatment. ConclusionsIgG4-RS could potentially develop with involvement of ocular adnexa, sinonasal cavities, ears, lymph nodes, skin and superficial soft tissue, and cranial nerves in the head and neck region. Immunomodulatory therapy could be effective in controlling both the comorbid diseases of IgG4-RS and sialadenitis of the major salivary glands. Level of Evidence4 Laryngoscope, 125:2113-2118, 2015

引用

页码：2113 / 2118

页数：6