A chiral probe for the acute phase proteins alpha-1-acid glycoprotein and alpha-1-antitrypsin based on europium luminescence

被引：43
作者：
Carr, Rachel [1 ]
Di Bari, Lorenzo [2 ]
Lo Piano, Samuele [2 ]
Parker, David [1 ]
Peacock, Robert D. [3 ]
Sanderson, John M. [1 ]
机构：
[1] Univ Durham, Dept Chem, Durham DH1 3LE, England
[2] Dipartimento Chim & Chim Ind, I-56126 Pisa, Italy
[3] Univ Glasgow, Dept Chem, Glasgow G12 8QQ, Lanark, Scotland
来源：
DALTON TRANSACTIONS | 2012年 / 41卷 / 42期
基金：
英国工程与自然科学研究理事会;
关键词：
CIRCULARLY-POLARIZED LUMINESCENCE; HUMAN SERUM-ALBUMIN; HUMAN ALPHA(1)-ACID GLYCOPROTEIN; EMISSIVE LANTHANIDE COMPLEXES; OPTICAL PROBES; CONTRAST AGENTS; DRUG-BINDING; LOCALIZATION PROFILE; GENETIC-VARIANTS; EXCITED-STATES;
D O I：
10.1039/c2dt30143a
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Reversible and selective binding of a dynamically racemic europium(III) complex to alpha(1)-acid glycoprotein and alpha(1)-antitrypsin is characterised by a significant change in the europium total emission spectral fingerprint and the switching on of a large circularly polarised luminescence (CPL) signal from the metal centre. Observation of an induced CD into the ligand chromophore in the presence of alpha(1)-AGP allows a structure for the protein-bound complex to be postulated. A direct determination of elevated alpha(1)-AGP levels in human serum was achieved by monitoring changes in the intensity ratio of Eu emission bands.
引用
收藏
页码：13154 / 13158
页数：5
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