The predictive effect of overexpressed miR-34a on good survival of cancer patients: a systematic review and meta-analysis

被引：16
作者：
Wang, Jian [1 ]
Dan, Guorong [1 ]
Zhao, Jiqing [1 ]
Ding, Yu [2 ]
Ye, Feng [1 ]
Sun, Huiqin [1 ]
Jiang, Fan [1 ]
Cheng, Jin [1 ]
Yuan, Fahuan [2 ]
Zou, Zhongmin [1 ]
机构：
[1] Third Mil Med Univ, Sch Prevent Med, Inst Toxicol, Chongqing 400038, Peoples R China
[2] Xinqiao Hosp, Dept Nephrol, Chongqing, Peoples R China
来源：
ONCOTARGETS AND THERAPY | 2015年 / 8卷
基金：
中国国家自然科学基金;
关键词：
meta-analysis; systematic review; miR-34a; cancer; prognosis; TUMOR-SUPPRESSOR; MICRORNA EXPRESSION; IDENTIFIES MIR-34A; GENE-EXPRESSION; P53; PROFILES; CHEMOTHERAPY; APOPTOSIS; NETWORK; GROWTH;
D O I：
10.2147/OTT.S84043
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Background: MicroRNA-34a (miR-34a) is a potential prognostic factor for survival in patients with several types of cancer according to previous clinical researches. We conducted a systematic review and meta-analysis to summarize the significance of increased miR-34a expression in the prognosis of patients' overall survival. Materials and methods: The present systematic review and meta-analysis of 15 researches included 2,597 patients. Overexpression of miR-34a may predict good overall survival ([OS], HR = 0.76, 95% confidence interval: 0.55-1.06, P=0.105), but the effect was not significant enough. Subgroup analysis results showed miR-34a was an ideal predictor for digestive system cancer (OS, HR = 0.50, 95% confidence interval: 0.25-0.99, P=0.048). The predictive effects of elevated expression of miR-34a on the OS of untreated and treated patients were not of obvious differences. Conclusion: This systematic review and meta-analysis showed that miR-34a has a predictive effect on overall survival of patients with digestive system cancer.
引用
收藏
页码：2709 / 2719
页数：11
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