Synthesis and biological evaluation of 2,3-diarylthiophenes as selective Cox-2 inhibitors .2. Replacing the heterocycle

被引：56

作者：

Gauthier, JY

Leblanc, Y

Black, WC

Chan, CC

Cromlish, WA

Gordon, R

Kennedey, BP

Lau, CK

Leger, S

Wang, ZY

Ethier, D

Guay, J

Mancini, J

Riendeau, D

Tagari, P

Vickers, P

Wong, E

Xu, LJ

Prasit, P

机构：

[1] Merck Frosst Ctr. Therapeut. Res., Dorval, Que. H9R 4P8

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 01期

关键词：

D O I：

10.1016/0960-894X(95)00564-A

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The thiophene ring of DuP 697 was replaced by a variety of heterocycles and the products were tested for their ability to inhibit human Cox-2 and Cox-1, the isozymes of cyclooxygenase.

引用

页码：87 / 92

页数：6

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