Relation of coronary hypersensitivity to serotonin in cardiac transplant recipients to vessel wall morphology and effect of vitamin C

被引:4
作者
Berkenboom, G [1 ]
Preumont, N
Pradier, O
Goldman, M
Carpentier, Y
Vachiery, JL
Antoine, M
机构
[1] Free Univ Brussels, Dept Cardiol, Brussels, Belgium
[2] Free Univ Brussels, Dept Immunol, Erasme Hosp, Brussels, Belgium
关键词
D O I
10.1016/j.amjcard.2005.09.088
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Coronary hypersensitivity to serotonin promotes platelet aggregation, entailing the progression of the atherosclerotic process. This abnormality is a common finding in cardiac transplant recipients and may be triggered by reactive oxygen species, which plays a main role in the inflammatory process. Hence, this study aimed to determine the influence of intimal hyperplasia on this abnormality and its reversibility after acute supplementation with the superoxide anion scavenger vitamin C. Therefore, intracoronary injections of serotonin (3 mu g), bradykinin (600 ng), and nitroglycerin (isosorbide dinitrate 200 mu g) were administered to 21 cardiac transplant recipients (1 year after transplantation) with normal coronary angiographic results; the serotonin injections were repeated after intracoronary vitamin C supplementation (40 mg/min for 14 minutes). In the segments in which serotonin effects were the most pronounced, the diameter changes were measured by quantitative angiography, and vessel wall morphology was studied by intravascular ultrasound (IVUS). The IVUS examination revealed moderate to severe intimal thickening (total area - luminal area/total area) in 9 patients (group 1) of 25 +/- 2%, compatible with the early stage of graft vasculopathy. In this group, hypersensitivity to serotonin remained unchanged after intracoronary vitamin C supplementation, from -21 +/- 3% (percentage from baseline) to -25 +/- 3%, whereas in the other 12 patients with mild intimal thickening (9 +/- 1%; group 2), hypersensitivity to serotonin was attenuated from -20 +/- 5% to -4 +/- 6% (p < 0.01). In contrast, the responses to bradykinin and isosorbide dinitrate were similar in the 2 groups. In group 1, plasma levels of high-sensitivity C-reactive protein and proinflammatory cytokines (interleukin-6 and -8) were significantly enhanced. For all the patients studied, the effect of vitamin C on the response to serotonin was significantly correlated with the intimal thickening. In conclusion, at I year after transplantation, morphologic changes compatible with the early stage of the graft vasculopathy are accompanied by hypersensitivity to serotonin unresponsive to vitamin C, despite a relatively preserved endothelial function (unaltered response to bradykinin). (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码:561 / 566
页数:6
相关论文
共 28 条
[1]   Effects of bradykinin on coronary blood flow and vasomotion in transplant patients [J].
Aptecar, E ;
Teiger, E ;
Dupouy, P ;
Benvenuti, C ;
Kern, MJ ;
Woscoboinik, J ;
Sediame, S ;
Pernes, JM ;
Castaigne, A ;
Loisance, D ;
Dubois-Randé, JL .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2000, 35 (06) :1607-1615
[2]   COMPARISON OF RESPONSES TO ACETYLCHOLINE AND SEROTONIN ON ISOLATED CANINE AND HUMAN CORONARY-ARTERIES [J].
BERKENBOOM, G ;
UNGER, P ;
ZHEN, YF ;
DEGRE, S ;
FONTAINE, J .
CARDIOVASCULAR RESEARCH, 1989, 23 (09) :780-787
[3]   Absence of L-arginine effect on coronary hypersensitivity to serotonin in cardiac transplant recipients [J].
Berkenboom, G ;
Crasset, V ;
Unger, P ;
Vachiery, JL ;
LeClerc, JL .
AMERICAN JOURNAL OF CARDIOLOGY, 1999, 84 (10) :1182-1186
[4]   5-HYDROXYTRYPTAMINE RECEPTOR PROFILE IN HEALTHY AND DISEASED HUMAN EPICARDIAL CORONARY-ARTERIES [J].
CHESTER, AH ;
MARTIN, GR ;
BODELSSON, M ;
ARNEKLONOBIN, B ;
TADJKARIMI, S ;
TORNEBRANDT, K ;
YACOUB, MH .
CARDIOVASCULAR RESEARCH, 1990, 24 (11) :932-937
[5]   Inflammation-induced endothelial dysfunction involves reduced nitric oxide bioavailability and increased oxidant stress [J].
Clapp, BR ;
Hingorani, AD ;
Kharbanda, RK ;
Mohamed-Ali, V ;
Stephens, JW ;
Vallance, P ;
MacAllister, RJ .
CARDIOVASCULAR RESEARCH, 2004, 64 (01) :172-178
[6]   Effect of vitamins C and E on progression of transplant-associated arteriosclerosis: a randomised trial [J].
Fang, JC ;
Kinlay, S ;
Beltrame, J ;
Hikiti, H ;
Wainstein, M ;
Behrendt, D ;
Suh, J ;
Frei, B ;
Mudge, GH ;
Selwyn, AP ;
Ganz, P .
LANCET, 2002, 359 (9312) :1108-1113
[7]   ASCORBATE IS AN OUTSTANDING ANTIOXIDANT IN HUMAN-BLOOD PLASMA [J].
FREI, B ;
ENGLAND, L ;
AMES, BN .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (16) :6377-6381
[8]   MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions [J].
Gerszten, RE ;
Garcia-Zepeda, EA ;
Lim, YC ;
Yoshida, M ;
Ding, HA ;
Gimbrone, MA ;
Luster, AD ;
Luscinskas, FW ;
Rosenzweig, A .
NATURE, 1999, 398 (6729) :718-723
[9]   Origin of neointimal endothelium and α-actin-positive smooth muscle cells in transplant arteriosclerosis [J].
Hillebrands, JL ;
Klatter, FA ;
van den Hurk, BMH ;
Popa, ER ;
Nieuwenhuis, P ;
Rozing, J .
JOURNAL OF CLINICAL INVESTIGATION, 2001, 107 (11) :1411-1422
[10]   Plasma C-reactive protein as a marker of cardiac allograft vasculopathy in heart transplant recipients [J].
Hognestad, A ;
Endresen, K ;
Wergeland, R ;
Stokke, O ;
Geiran, O ;
Holm, T ;
Simonsen, S ;
Kjekshus, JK ;
Andreassen, AK .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2003, 42 (03) :477-482