Evidence for glucocorticoid regulation of the rat vasopressin V-1a receptor gene

被引:9
作者
Watters, JJ
Swank, MW
Wilkinson, CW
Dorsa, DM
机构
[1] UNIV WASHINGTON,DEPT PSYCHIAT,SEATTLE,WA 98195
[2] FURMAN UNIV,DEPT PSYCHOL,GREENVILLE,SC 29613
[3] SEATTLE AMER LAKE VET ADM MED CTR,GRECC,SEATTLE,WA
[4] SEATTLE AMER LAKE VET ADM MED CTR,GRECC,TACOMA,WA
关键词
glucocorticoids; WRK-1; cells; liver; adrenalectomy; transcriptional regulation; aldosterone; glucocorticoid response element; messenger RNA; receptor binding;
D O I
10.1016/0196-9781(95)02085-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
WRK-1 cells express vasopressin V-1a receptors. Twenty-four-hour treatment of these cells with dexamethasone (DEX) resulted in an increase in [H-3]AVP binding that was maximal at 12 h, and could be blocked by addition of RU 38486. The increases in [H-3]AVP binding were paralleled by increases in V-1a receptor mRNA. The in vivo effects of glucocorticoids (GCs) on V-1a receptor binding in hepatic tissue were also investigated in adrenalectomized and hormone-replaced rats given either DEX or aldosterone (ALDO). DEX effectively increased V-1a receptor binding site density whereas ALDO had no effect. The DEX effects on V-1a receptor mRNA and binding strongly implicate glucocorticoids in the regulation of V-1a receptor gene expression.
引用
收藏
页码:67 / 73
页数:7
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