Association between METTL3 gene polymorphisms and neuroblastoma susceptibility: A nine-centre case-control study

被引：25

作者：

Bian, Jun ^{[1
]}

Zhuo, Zhenjian ^{[2
]}

Zhu, Jinhong ^{[3
]}

Yang, Zhonghua ^{[4
]}

Jiao, Zhang ^{[5
]}

Li, Yong ^{[6
]}

Cheng, Jiwen ^{[7
]}

Zhou, Haixia ^{[8
,9
]}

Li, Suhong ^{[10
]}

Li, Li ^{[11
]}

He, Jing ^{[2
]}

Liu, Yanfei ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Xian Childrens Hosp, Dept Gen Surg, Affiliated Childrens Hosp, 69 Xiju Court Lane, Xian 710003, Shaanxi, Peoples R China

[2] Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Guangzhou Inst Pediat, Dept Pediat Surg,Guangdong Prov Key Lab Res Struc, 9 Jinsui Rd, Guangzhou 510623, Guangdong, Peoples R China

[3] Harbin Med Univ Canc Hosp, Dept Clin Lab, Biobank, Harbin, Peoples R China

[4] China Med Univ, Shengjing Hosp, Dept Pediat Surg, Shenyang, Peoples R China

[5] Zhengzhou Univ, Affiliated Hosp 1, Dept Pediat Surg, Zhengzhou, Peoples R China

[6] Hunan Childrens Hosp, Dept Pediat Surg, Changsha, Peoples R China

[7] Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Pediat Surg, Xian, Peoples R China

[8] Wenzhou Med Univ, Affiliated Hosp 2, Dept Hematol, Wenzhou, Peoples R China

[9] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China

[10] Children Hosp & Women Hlth Ctr Shanxi, Dept Pathol, Taiyuan, Peoples R China

[11] Kunming Childrens Hosp, Kunming Key Lab Children Infect & Immun, Yunnan Key Lab Childrens Major Dis Res, Yunnan Inst Pediat,Yunnan Med Ctr Pediat Dis, Kunming, Yunnan, Peoples R China

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2020年 / 24卷 / 16期

关键词：

case-control study; METTL3; neuroblastoma; polymorphism; risk; XPG GENE; RISK; RNA; CANCER; VARIANTS; PROLIFERATION; MUTATIONS; MICRORNAS;

D O I：

10.1111/jcmm.15576

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Neuroblastoma ranks as the most commonly seen and deadly solid tumour in infancy. The aberrant activity of m(6)A-RNA methyltransferase METTL3 is involved in human cancers. Therefore, functional genetic variants in theMETTL3gene may contribute to neuroblastoma risk. In the current nine-centre case-control study, we aimed to analyse the association between theMETTL3gene single nucleotide polymorphisms (SNPs) and neuroblastoma susceptibility. We genotyped fourMETTL3gene SNPs (rs1061026 T>G, rs1061027 C>A, rs1139130 A>G, and rs1263801 G>C) in 968 neuroblastoma patients and 1814 controls in China. We found significant associations between these SNPs and neuroblastoma risk in neither single-locus nor combined analyses. Interestingly, in the stratified analysis, we observed a significant risk association with rs1061027 AA in subgroups of children <= 18 months of age (adjusted OR = 1.87, 95% CI = 1.03-3.41,P = .040) and females (adjusted OR = 1.86, 95% CI = 1.07-3.24,P = .028). Overall, we identified a significant association betweenMETTL3gene rs1061027 C>A polymorphism and neuroblastoma risk in children <= 18 months of age and females. Our findings provide novel insights into the genetic determinants of neuroblastoma.

引用

页码：9280 / 9286

页数：7