Embryonic stem cells: Similarities and differences between human and murine embryonic stem cells

被引:50
作者
Koestenbauer, S
Zech, NH
Juch, H
Vanderzwalmen, P
Schoonjans, L
Dohr, G
机构
[1] Med Univ Graz, Dept Cell Biol Histol & Embryol, Ctr Mol Biol, A-8010 Graz, Austria
[2] Univ Hosp, Dept Obstet & Gynaecol, Zurich, Switzerland
[3] Dept Reprod Med & Endocrinol, Bregenz, Austria
[4] Univ Leuven, Ctr Mol & Vasc Biol, Louvain, Belgium
关键词
embryonic stem cells; surface markers; transcription factors;
D O I
10.1111/j.1600-0897.2005.00354.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The derivation of murine embryonic stem (mES) cell lines was reported for the first time in 1981 (Nature, 1981; 292:154-156; Proc Natl Acad Sci U S A, 1981; 78:7634-7638), and they have since proved to be a very useful tool with which to study mammalian development, which is characterized by pluripotency and differentiation. About 20 years later, the successful generation of human embryonic stem (hES) cell lines was described (Science, 1998; 282:1145-1147). Although mES and hES are derived from mammals, they cannot be looked at as being one and the same. While basic information for hES can be derived from mES, such information does not correspond on a one-to-one basis. This review gives an overview of the characteristics of embryonic stem cells with the main focus on the similarities and differences between human and mES cells.
引用
收藏
页码:169 / 180
页数:12
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