Synthesis and self-assembly of "tree-like" amphiphilic glycopolypeptides

被引：67
|
作者：
Bonduelle, Colin [1 ,2 ]
Huang, Jin [3 ]
Ibarboure, Emmanuel [1 ,2 ]
Heise, Andreas [3 ]
Lecommandoux, Sebastien [1 ,2 ]
机构：
[1] Univ Bordeaux IPB, ENSCBP, F-33607 Pessac, France
[2] CNRS, UMR5629, Lab Chim Polymeres Organ, Pessac, France
[3] Dublin City Univ, Sch Chem Sci, Dublin 9, Ireland
来源：
CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 67期
基金：
爱尔兰科学基金会;
关键词：
BLOCK-COPOLYMERS; DRUG-DELIVERY; VESICLES; POLYMERSOMES; DOXORUBICIN; GLYCOPOLYMERS; MICELLES; WATER;
D O I：
10.1039/c2cc32970k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Novel synthetic tree-like oligosaccharides-grafted-polypeptides were prepared by using Huisgen 1,3-dipolar cycloaddition between poly(gamma-benzyl-L-glutamate)-block-poly(propargylglycine) and two different oligosaccharides, dextran or hyaluronan. By direct solubilisation in water, these tree- ike glycopeptides spontaneously form very small assemblies with sizes below 50 nm and low polydispersity.
引用
收藏
页码：8353 / 8355
页数：3
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