Ewing's sarcoma of jaw bones in adult patients: 10-year experiences in a Paris university hospital

被引:11
作者
Pitak-Arnnop, Poramate [1 ,2 ]
Bellefqih, Salima [3 ,4 ]
Bertolus, Chloe [1 ]
Chaine, Andre [1 ]
Dhanuthai, Kittipong [5 ]
Gruffaz, Francoise [3 ]
Bertrand, Jacques-Charles [1 ]
机构
[1] Univ Paris 06, Fac Med, Pitie Salpetriere Univ Hosp, Dept Maxillofacial Surg, F-75651 Paris 13, France
[2] Univ Paris 05, Fac Med, Lab Med Eth & Legal Med, Paris, France
[3] Univ Paris 06, Pitie Salpetriere Univ Hosp, Fac Med, Dept Anatom & Cytol Pathol, Paris, France
[4] Univ Hosp Reims, Fac Med, Dept Embryol Cytol Pathol & Mol Biol, Lab Pol Bouin, Reims, France
[5] Chulalongkorn Univ, Fac Dent, Dept Oral Pathol, Bangkok, Thailand
关键词
Ewing's sarcoma; jaw bone; Ki-67; adult; outcome; prognosis;
D O I
10.1016/j.jcms.2008.06.002
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Introduction: Despite using aggressive treatment, patients with Ewing's sarcoma (ES) always show a high recurrence and a low survival rate. Ki-67 has been used widely in surgical oncology. Patients and methods: This case report identified the Ki-67 expression in jaw bone ES from 4 adult patients operated upon between 1996 and 2005 in Pitie-Salpetriere University Hospital, Paris, France. The clinical data of each patient was also reviewed. Results: Ki-67 reactivity was found in 3 cases. Two of 4 patients with 50% and 80% of Ki-67 positive tumour cells had local relapse at 5 years and 8 months after treatments, respectively. Furthermore, the patient with 80%, Ki-67 expression exhibited resistance to chemotherapy and died a year after resection. The other 2 cases revealed no evidence of recurrence and metastasis to date. Conclusion: Ki-67 expression is likely to be associated with tumour recurrence and poor prognosis in jaw bone ES in adult patients. This marker probably helps surgeons to plan and employ appropriate treatment and/or surveillance for each patient; however, the number of cases in this series is very limited. A large-scale, prospective study, is, therefore, required to confirm our suggestion. (C) 2008 European Association for Cranio-Maxillofacial Surgery
引用
收藏
页码:450 / 455
页数:6
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