Epigenetic regulation of brain-derived neurotrophic factor: Implications in neurodevelopment and behavior

被引：4
|
作者：
Schanker, Benjamin D. [1 ,2 ]
机构：
[1] Massachusetts Gen Hosp, Psychiat & Neurodev Genet Unit, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Boston, MA 02115 USA
来源：
BEHAVIORAL AND BRAIN SCIENCES | 2012年 / 35卷 / 05期
关键词：
VAL66MET POLYMORPHISM; BDNF; EPISTASIS;
D O I：
10.1017/S0140525X12001100
中图分类号：
B84 [心理学];
学科分类号：
04 ; 0402 ;
摘要：
Several recent research findings have implicated brain-derived neurotrophic factor (BDNF) as a mediator of neuronal plasticity. The BDNF gene is under extensive epigenetic regulation, which modulates how much or how little environmental experiences become encoded within neurons and neural circuits. Future scientific progress within the postgenomic paradigm requires elucidation of the functional trajectory in neogenetic and environment interactions.
引用
收藏
页码：377 / 378
页数：2
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