Continuing harmonization of terminology and innovations for methodologies in developmental toxicology: Report of the 8th Berlin Workshop on Developmental Toxicity, 14-16 May 2014

被引：11

作者：

Solecki, Roland ^{[1
]}

Rauch, Martina ^{[1
]}

Gall, Andrea ^{[1
]}

Buschmann, Jochen ^{[2
]}

Clark, Ruth ^{[4
]}

Fuchs, Antje ^{[5
]}

Kan, Haidong ^{[6
]}

Heinrich, Verena ^{[1
]}

Kellner, Rupert ^{[2
]}

Knudsen, Thomas B. ^{[7
]}

Li, Weihua ^{[8
]}

Makris, Susan L. ^{[7
]}

Ooshima, Yojiro ^{[9
]}

Paumgartten, Francisco ^{[10
]}

Piersma, Aldert H. ^{[11
]}

Schoenfelder, Gilbert ^{[1
,3
]}

Oelgeschlaeger, Michael ^{[1
]}

Schaefer, Christof ^{[3
]}

Shiota, Kohei ^{[12
]}

Ulbrich, Beate

Ding, Xuncheng ^{[8
]}

Chahoud, Ibrahim ^{[3
]}

机构：

[1] Fed Inst Risk Assessment, Hannover, Germany

[2] Fraunhofer Inst Toxicol & Expt Med, Hannover, Germany

[3] Charite, D-13353 Berlin, Germany

[4] Ruth Clark Associates Ltd, Scunthorpe, England

[5] Covance Labs GmbH, Munster, Germany

[6] Fudan Univ, Shanghai 200433, Peoples R China

[7] US EPA, Washington, DC 20460 USA

[8] Shanghai Inst Planned Parenthood Res, Shanghai, Peoples R China

[9] Japanese Teratol Soc, Kagoshima, Japan

[10] Fundacao Oswaldo Cruz, Rio De Janeiro, Brazil

[11] RIVM Bilthoven, Bilthoven, Netherlands

[12] Shiga Univ Med Sci, Shiga, Japan

来源：

REPRODUCTIVE TOXICOLOGY | 2015年 / 57卷

关键词：

Malformation; Variation; Grey zone anomalies; Human anomalies; Developmental toxicology; Reproductive toxicology; Terminology; Harmonization; FETAL OBSERVATIONS; CLASSIFICATION;

D O I：

10.1016/j.reprotox.2015.06.046

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This article is a report of the 8th Berlin Workshop on Developmental Toxicity held in May 2014. The main aim of the workshop was the continuing harmonization of terminology and innovations for methodologies used in the assessment of embryo- and fetotoxic findings. The following main topics were discussed: harmonized categorization of external, skeletal, visceral and materno-fetal findings into malformations, variations and grey zone anomalies, aspects of developmental anomalies in humans and laboratory animals, and innovations for new methodologies in developmental toxicology. The application of Version 2 terminology in the DevTox database was considered as a useful improvement in the categorization of developmental anomalies. Participants concluded that initiation of a project for comparative assessments of developmental anomalies in humans and laboratory animals could support regulatory risk assessment and university-based training. Improvement of new methodological approaches for alternatives to animal testing should be triggered for a better understanding of developmental outcomes. (C) 2015 Published by Elsevier Inc.

引用

页码：140 / 146

页数：7

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