Rituximab as potential therapy for paraneoplastic cerebellar degeneration in pediatric Hodgkin disease

被引：9

作者：

Yeo, Kee Kiat ^{[1
]}

Walter, Andrew W. ^{[1
,2
]}

Miller, Robin E. ^{[1
,2
]}

Dalmau, Josep ^{[3
]}

机构：

[1] Thomas Jefferson Univ, Jefferson Med Coll, Philadelphia, PA 19107 USA

[2] Nemours Alfred I duPont Hosp Children, Dept Pediat, Div Pediat Hematol Oncol, Wilmington, DE USA

[3] Hosp Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA

来源：

PEDIATRIC BLOOD & CANCER | 2012年 / 58卷 / 06期

关键词：

Hodgkin; paraneoplastic cerebellar degeneration; rituximab; NEUROLOGICAL SYNDROMES; CHILD;

D O I：

10.1002/pbc.23314

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Paraneoplastic cerebellar degeneration (PCD) is a rare neurological syndrome associated with lung cancer, breast adenocarcinoma, ovarian adenocarcinoma, and Hodgkin disease. It is rarely seen in pediatrics. We report a case of a 10-year-old boy with a 2-year prodrome that led to a diagnosis of PCD in association with stage IV Hodgkin disease. He received radiation and chemotherapy for his Hodgkin disease with resolution of his lymphoma. Based on promising data in adults on the efficacy of rituximab over other immunosuppressive agents in paraneoplastic disorders, he was treated with rituximab with marked improvement of the cerebellar syndrome. Pediatr Blood Cancer 2012; 58: 986987. (C) 2011 Wiley Periodicals, Inc.

引用

页码：986 / 987

页数：2

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