Risk of benign meningioma after childhood cancer in the DCOG-LATER cohort: contributions of radiation dose, exposed cranial volume, and age

被引：37

作者：

Kok, Judith L. ^{[1
,2
]}

Teepen, Jop C. ^{[1
,2
]}

van Leeuwen, Flora E. ^{[3
]}

Tissing, Wim J. E. ^{[2
,4
]}

Neggers, Sebastian J. C. M. M. ^{[2
,5
]}

van der Pal, Helena J. ^{[2
]}

Loonen, Jacqueline J. ^{[6
]}

Bresters, Dorine ^{[2
]}

Versluys, Birgitta ^{[7
]}

van den Heuvel-Eibrink, Marry M. ^{[2
,8
]}

van Dulmen-den Broeder, Eline ^{[9
]}

van der Heiden-van der Loo, Margriet ^{[10
]}

Aleman, Berthe M. P. ^{[11
]}

Daniels, Laurien A. ^{[12
]}

Haasbeek, Cornelis J. A. ^{[13
]}

Hoeben, Bianca ^{[14
]}

Janssens, Geert O. ^{[2
,15
]}

Maduro, John H. ^{[16
]}

Oldenburger, Foppe ^{[17
]}

van Rij, Caroline ^{[18
]}

Tersteeg, Robbert J. H. A. ^{[15
]}

Hauptmann, Michael ^{[3
]}

Kremer, Leontien C. M. ^{[1
,2
]}

Ronckers, Cecile M. ^{[1
,2
]}

van den Berg, M. H. ^{[19
]}

Bruggink, A. H. ^{[20
]}

Caron, H. N. ^{[21
]}

Dolsma, W. V. ^{[22
]}

Grootenhuis, M. A. ^{[2
]}

den Hartogh, J. G. ^{[23
]}

Hollema, N. ^{[10
]}

Jongmans, M. C. ^{[2
,24
,25
]}

Jaspers, M. W. M. ^{[26
]}

Postma, A. ^{[10
]}

van de Vijver, M. J. ^{[26
]}

机构：

[1] Univ Amsterdam, Amsterdam UMC, Emma Childrens Hosp, Dept Pediat Oncol, Amsterdam, Netherlands

[2] Princess Maxima Ctr Pediat Oncol, POB 113, NL-3584 CS Utrecht, Netherlands

[3] Netherlands Canc Inst, Dept Epidemiol & Biostat, Amsterdam, Netherlands

[4] Univ Groningen, Univ Med Ctr Groningen, Beatrix Childrens Hosp, Dept Pediat Oncol Hematol, Groningen, Netherlands

[5] Erasmus MC, Sophia Childrens Hosp, Endocrinol Sect, Dept Pediat Oncol Hematol & Med, Rotterdam, Netherlands

[6] Radboud Univ Nijmegen, Med Ctr, Dept Hematol, Nijmegen, Netherlands

[7] Univ Med Ctr Utrecht, Wilhelmina Childrens Hosp, Dept Pediat Oncol & Hematol, Utrecht, Netherlands

[8] Erasmus MC, Sophia Childrens Hosp, Dept Pediat Oncol Hematol, Rotterdam, Netherlands

[9] Vrije Univ Amsterdam, Amsterdam UMC, Dept Pediat Oncol Hematol, Amsterdam, Netherlands

[10] Dutch Childhood Oncol Grp, Utrecht, Netherlands

[11] Netherlands Canc Inst, Dept Radiat Oncol, Amsterdam, Netherlands

[12] Leiden Univ, Med Ctr, Dept Radiat Oncol, Leiden, Netherlands

[13] Vrije Univ Amsterdam, Amsterdam UMC, Dept Radiat Oncol, Amsterdam, Netherlands

[14] Radboud Univ Nijmegen, Med Ctr, Dept Radiat Oncol, Nijmegen, Netherlands

[15] Univ Med Ctr Utrecht, Dept Radiat Oncol, Utrecht, Netherlands

[16] Univ Groningen, Univ Med Ctr Groningen, Dept Radiat Oncol, Groningen, Netherlands

[17] Univ Amsterdam, Amsterdam UMC, Dept Radiat Oncol, Amsterdam, Netherlands

[18] Erasmus MC, Dept Radiat Oncol, Rotterdam, Netherlands

[19] Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam, Netherlands

[20] PALGA Fdn, Houten, Netherlands

[21] Univ Amsterdam, Emma Childrens Amsterdam UMC, Amsterdam, Netherlands

[22] Univ Groningen, Univ Med Ctr Groningen, Groningen, Netherlands

[23] Dutch Childhood Canc Parent Org VOKK, Nieuwegein, Netherlands

[24] Radboud Univ Nijmegen Med Ctr, Nijmegen, Netherlands

[25] Univ Med Ctr Utrecht, Utrecht, Netherlands

[26] Univ Amsterdam, Amsterdam UMC, Amsterdam, Netherlands

来源：

NEURO-ONCOLOGY | 2019年 / 21卷 / 03期

关键词：

meningioma; cranial radiotherapy; childhood cancer survivors; radiation dose; radiation volume; ACUTE LYMPHOBLASTIC-LEUKEMIA; CENTRAL-NERVOUS-SYSTEM; TERM-FOLLOW-UP; SUBSEQUENT NEOPLASMS; INTENSIVE TREATMENT; 5-YEAR SURVIVORS; RADIOTHERAPY; PROTOCOL; TUMORS; CNS;

D O I：

10.1093/neuonc/noy124

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pediatric cranial radiotherapy (CrRT) markedly increases risk of meningiomas. We studied meningioma risk factors with emphasis on independent and joint effects of CrRT dose, exposed cranial volume, exposure age, and chemotherapy. The Dutch Cancer Oncology GroupLong-Term Effects after Childhood Cancer (DCOG-LATER) cohort includes 5-year childhood cancer survivors (CCSs) whose cancers were diagnosed in 19632001. Histologically confirmed benign meningiomas were identified from the population-based Dutch Pathology Registry (PALGA; 19902015). We calculated cumulative meningioma incidence and used multivariable Cox regression and linear excess relative risk (ERR) modeling. Among 5843 CCSs (median follow-up: 23.3 y, range: 5.052.2 y), 97 developed a benign meningioma, including 80 after full- and 14 after partial-volume CrRT. Compared with CrRT doses of 119 Gy, no CrRT was associated with a low meningioma risk (hazard ratio [HR] = 0.04, 95% CI: 0.010.15), while increased risks were observed for CrRT doses of 2039 Gy (HR = 1.66, 95% CI: 0.833.33) and 40+ Gy (HR = 2.81, 95% CI: 1.306.08). CCSs whose cancers were diagnosed before age 5 versus 1017 years showed significantly increased risks (HR = 2.38, 95% CI: 1.394.07). In this dose-adjusted model, volume was not significantly associated with increased risk (HR full vs partial = 1.66, 95% CI: 0.863.22). Overall, the ERR/Gy was 0.30 (95% CI: 0.03unknown). Dose effects did not vary significantly according to exposure age or CrRT volume. Cumulative incidence after any CrRT was 12.4% (95% CI: 9.8%15.2%) 40 years after primary cancer diagnosis. Among chemotherapy agents (including methotrexate and cisplatin), only carboplatin (HR = 3.55, 95% CI: 1.627.78) appeared associated with meningioma risk. However, we saw no carboplatin dose-response and all 9 exposed cases had high-dose CrRT. After CrRT 1 in 8 survivors developed late meningioma by age 40 years, associated with radiation dose and exposure age, relevant for future treatment protocols and awareness among survivors and physicians.

引用

页码：392 / 403

页数：12

共 20 条

[1] Morbidity and Mortality Associated With Meningioma After Cranial Radiotherapy: A Report From the Childhood Cancer Survivor Study
Bowers, Daniel C.
Moskowitz, Chaya S.
Chou, Joanne F.
Mazewski, Claire M.
Neglia, Joseph P.
Armstrong, Gregory T.
Leisenring, Wendy M.
Robison, Leslie L.
Oeffinger, Kevin C.
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2017, 35 (14) : 1570 - +
[2] Subsequent neoplasms of the CNS among survivors of childhood cancer: a systematic review
Bowers, Daniel C.
Nathan, Paul C.
Constine, Louis
Woodman, Catherine
Bhatia, Smita
Keller, Karen
Bashore, Lisa
[J]. LANCET ONCOLOGY, 2013, 14 (08) : E321 - E328
[3] Casparie M, 2007, CELL ONCOL, V29, P19
[4] Subsequent Neoplasms in 5-Year Survivors of Childhood Cancer: The Childhood Cancer Survivor Study
Friedman, Debra L.
Whitton, John
Leisenring, Wendy
Mertens, Ann C.
Hammond, Sue
Stovall, Marilyn
Donaldson, Sarah S.
Meadows, Anna T.
Robison, Leslie L.
Neglia, Joseph P.
[J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2010, 102 (14): : 1083 - 1095
[5] Gooley TA, 1999, STAT MED, V18, P695, DOI 10.1002/(SICI)1097-0258(19990330)18:6<695::AID-SIM60>3.3.CO
[6] 2-F
[7] International Guideline Harmonization Group, INT GUID HARM GROUP
[8] Kamps WA, 1999, BLOOD, V94, P1226
[9] A Worldwide Collaboration to Harmonize Guidelines for the Long-Term Follow-Up of Childhood and Young Adult Cancer Survivors: A Report From the International Late Effects of Childhood Cancer Guideline Harmonization Group
Kremer, Leontien C. M.
Mulder, Renee L.
Oeffinger, Kevin C.
Bhatia, Smita
Landier, Wendy
Levitt, Gill
Constine, Louis S.
Wallace, W. Hamish
Caron, Huib N.
Armenian, Saro H.
Skinner, Roderick
Hudson, Melissa M.
[J]. PEDIATRIC BLOOD & CANCER, 2013, 60 (04) : 543 - 549
[10] New primary neoplasms of the central nervous system in survivors of childhood cancer: a report from the childhood cancer survivor study
Neglia, Joseph P.
Robison, Leslie L.
Stovall, Marilyn
Liu, Yan
Packer, Roger J.
Hammond, Sue
Yasui, Yutaka
Kasper, Catherine E.
Mertens, Ann C.
Donaldson, Sarah S.
Meadows, Anna T.
Inskip, Peter D.
[J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2006, 98 (21) : 1528 - 1537

← 1 2 →