Effects of a chronic exercise training protocol on oxidative stress and right ventricular hypertrophy in monocrotaline-treated rats

被引:31
|
作者
Souza-Rabbo, Maristela P. [1 ,2 ]
Silva, Luis F. F. [1 ]
Auzani, Jorge A. S. [1 ]
Picoral, Marcus [1 ]
Khaper, Neelam [3 ]
Belló-Klein, Adriane [1 ]
机构
[1] Univ Fed Rio Grande do Sul, Cardiovasc Physiol Lab, BR-90050170 Porto Alegre, RS, Brazil
[2] Methodist Univ Ctr, Dept Res, Porto Alegre, RS, Brazil
[3] Lakehead Univ, No Ontario Sch Med, Thunder Bay, ON P7B 5E1, Canada
关键词
anti-oxidant enzymes; cor pulmonale; exercise training; pulmonary hypertension; reactive oxygen species; right ventricular hypertrophy;
D O I
10.1111/j.1440-1681.2008.04936.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
1. In the present study, we investigated the effects of exercise training on cardiac hypertrophy and oxidative stress in a monocrotaline (MCT)-induced cor pulmonale model. Male Wistar rats were assigned to one of three groups: sedentary control (SC); sedentary MCT (SM); or trained MCT (TM). 2. Right ventricular hypertrophy (RVH) was induced by a single injection of MCT (60 mg/kg, i.p.). Exercise training consisted of running on a treadmill (five times a week, during Weeks 3, 4 and 5). Systemic oxidative stress was evaluated in erythrocytes by chemiluminescence (CL) and the activity of the anti-oxidant enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione S-transferase (GST) was determined. 3. At Week 3, MCT-treated animals exhibited RVH, lung congestion, decreased SOD activity and increased CAT activity. Exercise training reduced MCT-induced RVH and increased GST activity. At Week 4, MCT-induced RVH was accompanied by an increase in CL and GST activity. However, in TM animals there was a decrease in CL and augmented SOD activity. At Week 5, there were no survivors in the SM group, whereas GST activity was elevated in TM rats compared with SC rats. There was no difference in GPx activity throughout the experimental protocol between the groups. 4. Taken together, our results indicate that exercise training is able to ameliorate RVH and improve survival, which is associated with a reduction in oxidative stress in MCT-treated rats.
引用
收藏
页码:944 / 948
页数:5
相关论文
共 50 条
  • [31] CHEMICAL SYMPATHECTOMY AND SEROTONIN INHIBITION REDUCE MONOCROTALINE-INDUCED RIGHT VENTRICULAR HYPERTROPHY IN RATS
    TUCKER, A
    BRYANT, SE
    FROST, HH
    MIGALLY, N
    CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1983, 61 (04) : 356 - 362
  • [32] Effects of a Pure α/β-Adrenergic Receptor Blocker on Monocrotaline-Induced Pulmonary Arterial Hypertension With Right Ventricular Hypertrophy in Rats
    Ishikawa, Masaya
    Sato, Naoki
    Asai, Kuniya
    Takano, Teruo
    Mizuno, Kyoichi
    CIRCULATION JOURNAL, 2009, 73 (12) : 2337 - 2341
  • [33] Arrhythmogenic substrate in hearts of rats with monocrotaline-induced pulmonary hypertension and right ventricular hypertrophy
    Benoist, David
    Stones, Rachel
    Drinkhill, Mark
    Bernus, Olivier
    White, Ed
    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2011, 300 (06): : H2230 - H2237
  • [34] Effects of Intermittent Normoxia on Chronic Hypoxic Pulmonary Hypertension and Right Ventricular Hypertrophy in Rats
    Liu, Chunlei
    Chen, Xu
    Guo, Ge
    Xu, Xiang
    Li, Xin
    Wei, Qingxia
    Shen, Yanying
    Li, Hanlu
    Hao, Jianxiu
    Tian, Ya Ping
    He, Kunlun
    HIGH ALTITUDE MEDICINE & BIOLOGY, 2021, 22 (02) : 184 - 192
  • [35] Elevated oxidative stress and endothelial dysfunction in right coronary artery of right ventricular hypertrophy
    Lu, Xiao
    Dang, Charles Q.
    Guo, Xiaomei
    Molloi, Sabee
    Wassall, Cynthia D.
    Kemple, Marvin D.
    Kassab, Ghassan S.
    JOURNAL OF APPLIED PHYSIOLOGY, 2011, 110 (06) : 1674 - 1681
  • [36] Cardiac β-adrenoceptor changes in monocrotaline-treated rats:: Differences between membrane preparations from whole ventricles and isolated ventricular cardiomyocytes
    Leineweber, K
    Seyfarth, T
    Abraham, G
    Gerbershagen, HP
    Heinroth-Hoffmann, I
    Pönicke, K
    Brodde, OE
    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2003, 41 (03) : 333 - 342
  • [37] Effects of Exercise Training on NASH-Induced Oxidative Stress in Heart of Rats
    Huang, Wei-Chih
    Chan, Che-Chang
    Hung, Shan-Ken
    Yang, Ai-Lun
    Tsai, Shiow-Chwen
    FASEB JOURNAL, 2012, 26
  • [38] EFFECTS OF AEROBIC EXERCISE TRAINING ON OXIDATIVE STRESS IN THE SKELETAL MUSCLES OF OBESE RATS
    Souza Farias Ulbricht, Arlene Sampaio
    Delwing-de Lima, Daniela
    Werlang-Coelho, Carla
    Delwing-Dal Magro, Debora
    Donat, Bruna
    Vieira, Mariana Ramos
    Poletto, Marina Zordan
    Pereira, Eduardo Manoel
    REVISTA BRASILEIRA DE MEDICINA DO ESPORTE, 2019, 25 (05) : 404 - 408
  • [39] Effects of exercise training on hepatic oxidative stress and antioxidant status in aged rats
    Okudan, N.
    Belviranli, M.
    ACTA PHYSIOLOGICA, 2016, 216
  • [40] Effects of exercise training on hepatic oxidative stress and antioxidant status in aged rats
    Okudan, Nilsel
    Belviranli, Muaz
    ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY, 2016, 122 (04) : 180 - 185