Effects of a chronic exercise training protocol on oxidative stress and right ventricular hypertrophy in monocrotaline-treated rats
被引:31
|
作者:
Souza-Rabbo, Maristela P.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Rio Grande do Sul, Cardiovasc Physiol Lab, BR-90050170 Porto Alegre, RS, Brazil
Methodist Univ Ctr, Dept Res, Porto Alegre, RS, BrazilUniv Fed Rio Grande do Sul, Cardiovasc Physiol Lab, BR-90050170 Porto Alegre, RS, Brazil
Souza-Rabbo, Maristela P.
[1
,2
]
Silva, Luis F. F.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Rio Grande do Sul, Cardiovasc Physiol Lab, BR-90050170 Porto Alegre, RS, BrazilUniv Fed Rio Grande do Sul, Cardiovasc Physiol Lab, BR-90050170 Porto Alegre, RS, Brazil
Silva, Luis F. F.
[1
]
Auzani, Jorge A. S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Rio Grande do Sul, Cardiovasc Physiol Lab, BR-90050170 Porto Alegre, RS, BrazilUniv Fed Rio Grande do Sul, Cardiovasc Physiol Lab, BR-90050170 Porto Alegre, RS, Brazil
Auzani, Jorge A. S.
[1
]
Picoral, Marcus
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Rio Grande do Sul, Cardiovasc Physiol Lab, BR-90050170 Porto Alegre, RS, BrazilUniv Fed Rio Grande do Sul, Cardiovasc Physiol Lab, BR-90050170 Porto Alegre, RS, Brazil
Picoral, Marcus
[1
]
Khaper, Neelam
论文数: 0引用数: 0
h-index: 0
机构:
Lakehead Univ, No Ontario Sch Med, Thunder Bay, ON P7B 5E1, CanadaUniv Fed Rio Grande do Sul, Cardiovasc Physiol Lab, BR-90050170 Porto Alegre, RS, Brazil
Khaper, Neelam
[3
]
Belló-Klein, Adriane
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Rio Grande do Sul, Cardiovasc Physiol Lab, BR-90050170 Porto Alegre, RS, BrazilUniv Fed Rio Grande do Sul, Cardiovasc Physiol Lab, BR-90050170 Porto Alegre, RS, Brazil
Belló-Klein, Adriane
[1
]
机构:
[1] Univ Fed Rio Grande do Sul, Cardiovasc Physiol Lab, BR-90050170 Porto Alegre, RS, Brazil
[2] Methodist Univ Ctr, Dept Res, Porto Alegre, RS, Brazil
[3] Lakehead Univ, No Ontario Sch Med, Thunder Bay, ON P7B 5E1, Canada
1. In the present study, we investigated the effects of exercise training on cardiac hypertrophy and oxidative stress in a monocrotaline (MCT)-induced cor pulmonale model. Male Wistar rats were assigned to one of three groups: sedentary control (SC); sedentary MCT (SM); or trained MCT (TM). 2. Right ventricular hypertrophy (RVH) was induced by a single injection of MCT (60 mg/kg, i.p.). Exercise training consisted of running on a treadmill (five times a week, during Weeks 3, 4 and 5). Systemic oxidative stress was evaluated in erythrocytes by chemiluminescence (CL) and the activity of the anti-oxidant enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione S-transferase (GST) was determined. 3. At Week 3, MCT-treated animals exhibited RVH, lung congestion, decreased SOD activity and increased CAT activity. Exercise training reduced MCT-induced RVH and increased GST activity. At Week 4, MCT-induced RVH was accompanied by an increase in CL and GST activity. However, in TM animals there was a decrease in CL and augmented SOD activity. At Week 5, there were no survivors in the SM group, whereas GST activity was elevated in TM rats compared with SC rats. There was no difference in GPx activity throughout the experimental protocol between the groups. 4. Taken together, our results indicate that exercise training is able to ameliorate RVH and improve survival, which is associated with a reduction in oxidative stress in MCT-treated rats.
机构:
Okayama Univ, Dept Prevent Dent, Grad Sch Med Dent & Pharmaceut Sci, Kita Ku, Okayama 7008558, JapanOkayama Univ, Dept Prevent Dent, Grad Sch Med Dent & Pharmaceut Sci, Kita Ku, Okayama 7008558, Japan
Azuma, Tetsuji
Tomofuji, Takaaki
论文数: 0引用数: 0
h-index: 0
机构:
Okayama Univ, Dept Prevent Dent, Grad Sch Med Dent & Pharmaceut Sci, Kita Ku, Okayama 7008558, JapanOkayama Univ, Dept Prevent Dent, Grad Sch Med Dent & Pharmaceut Sci, Kita Ku, Okayama 7008558, Japan
Tomofuji, Takaaki
Endo, Yasumasa
论文数: 0引用数: 0
h-index: 0
机构:
Okayama Univ, Dept Prevent Dent, Grad Sch Med Dent & Pharmaceut Sci, Kita Ku, Okayama 7008558, JapanOkayama Univ, Dept Prevent Dent, Grad Sch Med Dent & Pharmaceut Sci, Kita Ku, Okayama 7008558, Japan
Endo, Yasumasa
Tamaki, Naofumi
论文数: 0引用数: 0
h-index: 0
机构:
Okayama Univ, Dept Prevent Dent, Grad Sch Med Dent & Pharmaceut Sci, Kita Ku, Okayama 7008558, JapanOkayama Univ, Dept Prevent Dent, Grad Sch Med Dent & Pharmaceut Sci, Kita Ku, Okayama 7008558, Japan
Tamaki, Naofumi
Ekuni, Daisuke
论文数: 0引用数: 0
h-index: 0
机构:
Okayama Univ, Dept Prevent Dent, Grad Sch Med Dent & Pharmaceut Sci, Kita Ku, Okayama 7008558, JapanOkayama Univ, Dept Prevent Dent, Grad Sch Med Dent & Pharmaceut Sci, Kita Ku, Okayama 7008558, Japan
Ekuni, Daisuke
Irie, Koichiro
论文数: 0引用数: 0
h-index: 0
机构:
Okayama Univ, Dept Prevent Dent, Grad Sch Med Dent & Pharmaceut Sci, Kita Ku, Okayama 7008558, JapanOkayama Univ, Dept Prevent Dent, Grad Sch Med Dent & Pharmaceut Sci, Kita Ku, Okayama 7008558, Japan
Irie, Koichiro
Kasuyama, Kenta
论文数: 0引用数: 0
h-index: 0
机构:
Okayama Univ, Dept Prevent Dent, Grad Sch Med Dent & Pharmaceut Sci, Kita Ku, Okayama 7008558, JapanOkayama Univ, Dept Prevent Dent, Grad Sch Med Dent & Pharmaceut Sci, Kita Ku, Okayama 7008558, Japan
Kasuyama, Kenta
Kato, Tomo
论文数: 0引用数: 0
h-index: 0
机构:
Okayama Univ, Dept Prevent Dent, Grad Sch Med Dent & Pharmaceut Sci, Kita Ku, Okayama 7008558, JapanOkayama Univ, Dept Prevent Dent, Grad Sch Med Dent & Pharmaceut Sci, Kita Ku, Okayama 7008558, Japan
Kato, Tomo
Morita, Manabu
论文数: 0引用数: 0
h-index: 0
机构:
Okayama Univ, Dept Prevent Dent, Grad Sch Med Dent & Pharmaceut Sci, Kita Ku, Okayama 7008558, JapanOkayama Univ, Dept Prevent Dent, Grad Sch Med Dent & Pharmaceut Sci, Kita Ku, Okayama 7008558, Japan
机构:
Univ Sao Paulo, Sch Med, Inst Heart, BR-05508 Sao Paulo, BrazilUniv Sao Paulo, Sch Med, Inst Heart, BR-05508 Sao Paulo, Brazil
Sirvente, R.
Mendes, R. H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Rio Grande do Sul, BR-90046900 Porto Alegre, RS, BrazilUniv Sao Paulo, Sch Med, Inst Heart, BR-05508 Sao Paulo, Brazil
Mendes, R. H.
Candido, G. O.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Sch Med, Inst Heart, BR-05508 Sao Paulo, BrazilUniv Sao Paulo, Sch Med, Inst Heart, BR-05508 Sao Paulo, Brazil
Candido, G. O.
Mostarda, C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Sch Med, Inst Heart, BR-05508 Sao Paulo, BrazilUniv Sao Paulo, Sch Med, Inst Heart, BR-05508 Sao Paulo, Brazil
Mostarda, C.
Jorge, L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Sch Med, Inst Heart, BR-05508 Sao Paulo, BrazilUniv Sao Paulo, Sch Med, Inst Heart, BR-05508 Sao Paulo, Brazil
Jorge, L.
Bello-Klein, A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Rio Grande do Sul, BR-90046900 Porto Alegre, RS, BrazilUniv Sao Paulo, Sch Med, Inst Heart, BR-05508 Sao Paulo, Brazil
Bello-Klein, A.
Rigatto, K.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Rio Grande do Sul, BR-90046900 Porto Alegre, RS, Brazil
Fed Fed Fac Med Sci Porto Alegre, Porto Alegre, RS, BrazilUniv Sao Paulo, Sch Med, Inst Heart, BR-05508 Sao Paulo, Brazil
Rigatto, K.
Irigoyen, Mc.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Sch Med, Inst Heart, BR-05508 Sao Paulo, Brazil
Univ Fed Rio Grande do Sul, BR-90046900 Porto Alegre, RS, BrazilUniv Sao Paulo, Sch Med, Inst Heart, BR-05508 Sao Paulo, Brazil
机构:
Tohoku Univ, Div Clin Pharmacol & Therapeut, Grad Sch Pharmaceut Sci, Sendai, Miyagi 9808576, Japan
Tohoku Univ, Dept Internal Med & Rehabil Sci, Grad Sch Med, Sendai, Miyagi 9808574, Japan
Tohoku Med & Pharmaceut Univ, Div Integrat Renal Replacement Therapy, Sendai, Miyagi 9838536, JapanTohoku Univ, Div Clin Pharmacol & Therapeut, Grad Sch Pharmaceut Sci, Sendai, Miyagi 9808576, Japan
Yamakoshi, Seiko
Nakamura, Takahiro
论文数: 0引用数: 0
h-index: 0
机构:
Tohoku Univ, Dept Internal Med & Rehabil Sci, Grad Sch Med, Sendai, Miyagi 9808574, JapanTohoku Univ, Div Clin Pharmacol & Therapeut, Grad Sch Pharmaceut Sci, Sendai, Miyagi 9808576, Japan
Nakamura, Takahiro
Xu, Lusi
论文数: 0引用数: 0
h-index: 0
机构:
Tohoku Med & Pharmaceut Univ, Fac Med, Div Gen Med & Rehabil, Sendai, Miyagi 9838536, JapanTohoku Univ, Div Clin Pharmacol & Therapeut, Grad Sch Pharmaceut Sci, Sendai, Miyagi 9808576, Japan
Xu, Lusi
Kohzuki, Masahiro
论文数: 0引用数: 0
h-index: 0
机构:
Tohoku Univ, Dept Internal Med & Rehabil Sci, Grad Sch Med, Sendai, Miyagi 9808574, JapanTohoku Univ, Div Clin Pharmacol & Therapeut, Grad Sch Pharmaceut Sci, Sendai, Miyagi 9808576, Japan
Kohzuki, Masahiro
Ito, Osamu
论文数: 0引用数: 0
h-index: 0
机构:
Tohoku Med & Pharmaceut Univ, Fac Med, Div Gen Med & Rehabil, Sendai, Miyagi 9838536, JapanTohoku Univ, Div Clin Pharmacol & Therapeut, Grad Sch Pharmaceut Sci, Sendai, Miyagi 9808576, Japan