Dendrimers for pharmaceutical and biomedical applications

被引：142
作者：
Yang, H
Kao, WYJ
机构：
[1] Univ Wisconsin, Sch Pharm, Madison, WI 53705 USA
[2] Univ Wisconsin, Coll Engn, Dept Biomed Engn, Madison, WI 53705 USA
来源：
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION | 2006年 / 17卷 / 1-2期
关键词：
dendrimer; biomaterials; nanomedicine; drug delivery; polyamidoamine (PAMAM) dendrimer;
D O I：
10.1163/156856206774879171
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Dendrimers are a unique class of synthetic macromolecules having a highly branched, three-dimensional, nanoscale architecture with very low polydispersity and high functionality. Structural advantages allow dendrimers to play an important role in the fields of nanotechnology, pharmaceutical and medicinal chemistry. This review discusses several aspects of dendrimers, including preparation, dendrimer-drug coupling chemistry, structural models of dendrimer-based drug delivery systems, and physicochemical and toxicological properties.
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页码：3 / 19
页数：17
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