FBXW7 in Cancer: What Has Been Unraveled Thus Far?

被引：129

作者：

Sailo, Bethsebie Lalduhsaki ^{[1
,2
]}

Banik, Kishore ^{[1
,2
]}

Girisa, Sosmitha ^{[1
,2
]}

Bordoloi, Devivasha ^{[1
,2
]}

Fan, Lu ^{[3
]}

Halim, Clarissa Esmeralda ^{[3
]}

Wang, Hong ^{[3
]}

Kumar, Alan Prem ^{[3
,4
,5
,6
]}

Zheng, Dali ^{[7
]}

Mao, Xinliang ^{[8
,9
]}

Sethi, Gautam ^{[3
]}

Kunnumakkara, Ajaikumar Bahulayan ^{[1
,2
]}

机构：

[1] Indian Inst Technol Guwahati, Dept Biosci & Bioengn, Canc Biol Lab, Gauhati 781039, Assam, India

[2] Indian Inst Technol Guwahati, Dept Biosci & Bioengn, DAILAB, Gauhati 781039, Assam, India

[3] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore 117600, Singapore

[4] Natl Univ Singapore, Canc Sci Inst Singapore, Singapore 117600, Singapore

[5] Natl Univ Singapore, Yong Loo Lin Sch Med, Med Sci Cluster, Singapore 117600, Singapore

[6] Curtin Univ, Curtin Med Sch, Fac Hlth Sci, Perth, WA 6845, Australia

[7] Fujian Med Univ, Sch Stomatol, 1 Xue Yuan Rd, Fuzhou 350108, Fujian, Peoples R China

[8] Guangzhou Univ Chinese Med, Inst Clin Pharmacol, 12 Jichang Rd, Guangzhou 510405, Guangdong, Peoples R China

[9] Soochow Univ, Dept Pharmacol, Coll Pharmaceut Sci, 199 Renai Rd, Suzhou 215123, Jiangsu, Peoples R China

来源：

CANCERS | 2019年 / 11卷 / 02期

关键词：

FBXW7; SCF complex; tumor suppressor; mutations; cancer; chemoresistance; chemosensitization; NF-KAPPA-B; PROMOTES CELL-PROLIFERATION; XENOGRAFT MOUSE MODEL; HUMAN GASTRIC-CANCER; EPITHELIAL-MESENCHYMAL TRANSITION; HUMAN HEPATOCELLULAR-CARCINOMA; ACUTE LYMPHOBLASTIC-LEUKEMIA; UBIQUITIN LIGASE COMPLEX; CYCLIN-E DEGRADATION; F-BOX PROTEINS;

D O I：

10.3390/cancers11020246

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The FBXW7 (F-box with 7 tandem WD40) protein encoded by the gene FBXW7 is one of the crucial components of ubiquitin ligase called Skp1-Cullin1-F-box (SCF) complex that aids in the degradation of many oncoproteins via the ubiquitin-proteasome system (UPS) thus regulating cellular growth. FBXW7 is considered as a potent tumor suppressor as most of its target substrates can function as potential growth promoters, including c-Myc, Notch, cyclin E, c-JUN, and KLF5. Its regulators include p53, C/EBP-delta, Numb, microRNAs, Pin 1, Hes-5, BMI1, Ebp2. Mounting evidence has indicated the involvement of aberrant expression of FBXW7 for tumorigenesis. Moreover, numerous studies have also shown its role in cancer cell chemosensitization, thereby demonstrating the importance of FBXW7 in the development of curative cancer therapy. This comprehensive review emphasizes on the targets, functions, regulators and expression of FBXW7 in different cancers and its involvement in sensitizing cancer cells to chemotherapeutic drugs.

引用

页数：31

共 207 条

[1] FBXW7 regulates a mitochondrial transcription program by modulating MITF
Abbate, Franco
Badal, Brateil
Mendelson, Karen
Aydin, Iraz T.
Serasinghe, Madhavika N.
Iqbal, Ramiz
Mohammed, Jarvier N.
Solovyov, Alexander
Greenbaum, Benjamin D.
Chipuk, Jerry E.
Celebi, Julide T.
[J]. PIGMENT CELL & MELANOMA RESEARCH, 2018, 31 (05) : 636 - 640
[2] Nuclear factor-kappa B: From clone to clinic
Ahn, Kwang Seok
Sethi, Gautam
Aggarwal, Bharat B.
[J]. CURRENT MOLECULAR MEDICINE, 2007, 7 (07) : 619 - 637
[3] FBXW7/hCDC4 is a general tumor suppressor in human cancer
Akhoondi, Shahab
Sun, Dahui
von der Lehr, Natalie
Apostolidou, Sophia
Klotz, Kathleen
Maljukova, Alena
Cepeda, Diana
Fiegl, Heidi
Dofou, Dimitra
Marth, Christian
Mueller-Holzner, Elisabeth
Corcoran, Martin
Dagnell, Markus
Nejad, Sepideh Zabihi
Nayer, Babak Noori
Zali, Mohammad Reza
Hansson, Johan
Egyhazi, Susanne
Petersson, Fredrik
Sangfelt, Per
Nordgren, Hans
Grander, Dan
Reed, Steven I.
Widschwendter, Martin
Sangfelt, Olle
Spruck, Charles
[J]. CANCER RESEARCH, 2007, 67 (19) : 9006 - 9012
[4] Inactivation of FBXW7/hCDC4-β expression by promoter hypermethylation is associated with favorable prognosis in primary breast cancer
Akhoondi, Shahab
Lindstrom, Linda
Widschwendter, Martin
Corcoran, Martin
Bergh, Jonas
Spruck, Charles
Grander, Dan
Sangfelt, Olle
[J]. BREAST CANCER RESEARCH, 2010, 12 (06):
[5] Quantitative assessment of telomerase components in cancer cell lines
Akincilar, Semih Can
Low, Kee Chung
Liu, Chia Yi
Yan, Ting Dong
Oji, Asami
Ikawa, Masahito
Li, Shang
Tergaonkar, Vinay
[J]. FEBS LETTERS, 2015, 589 (09) : 974 - 984
[6] [Anonymous], 2017, Tumour Biol. : J. Int. Soc. Oncodevelopm. Biol. Medi
[7] Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway
Arabi, Azadeh
Ullah, Karim
Branca, Rui M. M.
Johansson, Johan
Bandarra, Daniel
Haneklaus, Moritz
Fu, Jing
Aries, Ingrid
Nilsson, Peter
Den Boer, Monique L.
Pokrovskaja, Katja
Grander, Dan
Xiao, Gutian
Rocha, Sonia
Lehtio, Janne
Sangfelt, Olle
[J]. NATURE COMMUNICATIONS, 2012, 3
[8] NOTCH1/FBXW7 mutation identifies a large subgroup with favorable outcome in adult T-cell acute lymphoblastic leukemia (T-ALL): a Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) study
Asnafi, Vahid
Buzyn, Agnes
Le Noir, Sandrine
Baleydier, Frederic
Simon, Arnauld
Beldjord, Kheira
Reman, Oumedaly
Witz, Francis
Fagot, Thierry
Tavernier, Emmanuelle
Turlure, Pascal
Leguay, Thibaut
Huguet, Francoise
Vernant, Jean-Paul
Daniel, Francis
Bene, Marie-Christine
Ifrah, Norbert
Thomas, Xavier
Dombret, Herve
Macintyre, Elizabeth
[J]. BLOOD, 2009, 113 (17) : 3918 - 3924
[9] FBXW7 Mutations in Melanoma and a New Therapeutic Paradigm
Aydin, Iraz T.
Melamed, Rachel D.
Adams, Sarah J.
Castillo-Martin, Mireia
Demir, Ahu
Bryk, Diana
Brunner, Georg
Cordon-Cardo, Carlos
Osman, Iman
Rabadan, Raul
Celebi, Julide Tok
[J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2014, 106 (06):
[10] Ginkgolic Acid Inhibits Invasion and Migration and TGF--Induced EMT of Lung Cancer Cells Through PI3K/Akt/mTOR Inactivation
Baek, Seung Ho
Ko, Jeong-Hyeon
Lee, Jong Hyun
Kim, Chulwon
Lee, Hanwool
Nam, Dongwoo
Lee, Junhee
Lee, Seok-Geun
Yang, Woong Mo
Um, Jae-Young
Sethi, Gautam
Ahn, Kwang Seok
[J]. JOURNAL OF CELLULAR PHYSIOLOGY, 2017, 232 (02) : 346 - 354

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