CRISPR/Cas9 Genome-Editing Technology and Potential Clinical Application in Gastric Cancer

被引：7

作者：

Almeida, Renata Sanches ^{[1
]}

Wisnieski, Fernanda ^{[1
,2
]}

Real Karia, Bruno Takao ^{[1
]}

Cardoso Smith, Marilia Arruda ^{[1
]}

机构：

[1] Univ Fed Sao Paulo, Dept Morphol & Genet, Discipline Genet, Rua Botucatu 740, BR-04023900 Sao Paulo, Brazil

[2] Univ Fed Sao Paulo, Dept Med, Discipline Gastroenterol, Rua Loefgreen 1726, BR-04023900 Sao Paulo, Brazil

来源：

GENES | 2022年 / 13卷 / 11期

基金：

巴西圣保罗研究基金会;

关键词：

gastric cancer; CRISPR; gene editing; GENE-EXPRESSION; HUMAN-CELLS; DNA; IDENTIFICATION; CAS; ACTIVATION; RESISTANCE; MIGRATION; INVASION; SEQUENCE;

D O I：

10.3390/genes13112029

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Gastric cancer is the subject of clinical and basic studies due to its high incidence and mortality rates worldwide. Due to the diagnosis occurring in advanced stages and the classic treatment methodologies such as gastrectomy and chemotherapy, they are extremely aggressive and limit the quality of life of these patients. CRISPR/Cas9 is a tool that allows gene editing and has been used to explore the functions of genes related to gastric cancer, in addition to being used in the treatment of this neoplasm, greatly increasing our understanding of cancer genomics. In this mini-review, we seek the current status of the CRISPR/Cas9 gene-editing technology in gastric cancer research and clinical research.

引用

页数：13

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