Does the level of serum antimullerian hormone predict ovulatory function in women with polycystic ovary syndrome with aging?

Objective: To determine possible prediction of regular menses with aging in anovulatory women with polycystic ovary syndrome (PCOS). Design: Cohort. Setting: Academic practice. Patient(s): A total of 54 anovulatory women with PCOS and 28 age-and weight-matched control subjects. Intervention(s): Blood and ovarian ultrasound at baseline and after 5 years. Major Outcome Measure(s): Serum antimullerian hormone (AMH), gonadotropins, androgens, insulin sensitivity, and ovarian ultrasound. Result(s): After 5 years, there was a significant decrease in AMH in women with PCOS and control subjects (10 of 54 anovulatory women became ovulatory after 5 years). There was a significant negative correlation between baseline serum AMH and ovulatory function after 5 years. However, baseline serum AMH <= 4 ng/mL was associated with ovulatory function. Conclusion(s): Serum AMH may help predict ovulatory function with aging in anovulatory women with PCOS. (Fertil Steril (R) 2012;98:1043-6. (C)2012 by American Society for Reproductive Medicine.)