You may need the vagus nerve to understand pathophysiology and to treat diseases
被引:64
作者:
De Couck, Marijke
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Vrije Univ Brussel, Fac Med & Pharm, Brussels, BelgiumVrije Univ Brussel, Fac Med & Pharm, Brussels, Belgium
De Couck, Marijke
[1
]
Mravec, Boris
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机构:
Comenius Univ, Fac Med, Inst Pathophysiol, Bratislava, Slovakia
Slovak Acad Sci, Inst Expt Endocrinol, Bratislava, SlovakiaVrije Univ Brussel, Fac Med & Pharm, Brussels, Belgium
Mravec, Boris
[2
,3
]
Gidron, Yori
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机构:
Vrije Univ Brussel, Fac Med & Pharm, Brussels, BelgiumVrije Univ Brussel, Fac Med & Pharm, Brussels, Belgium
Gidron, Yori
[1
]
机构:
[1] Vrije Univ Brussel, Fac Med & Pharm, Brussels, Belgium
[2] Comenius Univ, Fac Med, Inst Pathophysiol, Bratislava, Slovakia
[3] Slovak Acad Sci, Inst Expt Endocrinol, Bratislava, Slovakia
Can different pathophysiological mechanisms and risk factors leading to various diseases be linked with altered transmission of signals by one common pathway? The present article provides evidence for the hypothesis that adequate vagal nerve activity reduces the risk of major diseases, via common basic mechanisms and interim risk factors. These diseases include cardiovascular disease, cancer, Alzheimer's disease and the metabolic syndrome. Three basic mechanisms contribute to such illnesses: local oxidative stress and DNA damage, inflammatory reactions and excessive sympathetic responses, all of which are inhibited by vagal nerve activity. Efferent vagal activity that can be non-invasively measured by HRV (heart rate variability), derived from an ECG, is inversely related to all three basic mechanisms, to various risk factors (e.g. diabetes and dyslipidaemia) and, more broadly, to the diseases as well. Finally, vagal activity is proposed to moderate the effects of risk factors on developing such illnesses. By proposing an integrative neurobiological model of major diseases, identifying people at risk for, and treating patients with, such diseases may be done more efficiently. People with low HRV may be identified and subsequently treated by vagus nerve activation to possibly prevent or treat such illnesses. This proposed disease paradigm may have important preventative and therapeutic implications, whose clinical effects need to be investigated.
机构:
Seoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
Seoul Natl Univ, SNUMRC, Neurosci Res Inst, Program Neurosci, Seoul, South KoreaSeoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
Lee, Soon-Tae
Chu, Kon
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Seoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
Seoul Natl Univ, SNUMRC, Neurosci Res Inst, Program Neurosci, Seoul, South KoreaSeoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
Chu, Kon
Jung, Keun-Hwa
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Seoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
Seoul Natl Univ, SNUMRC, Neurosci Res Inst, Program Neurosci, Seoul, South KoreaSeoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
Jung, Keun-Hwa
Kang, Kyung-Mook
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Seoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South KoreaSeoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
Kang, Kyung-Mook
Kim, Jin-Hee
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Seoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
Seoul Natl Univ, SNUMRC, Neurosci Res Inst, Program Neurosci, Seoul, South KoreaSeoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
Kim, Jin-Hee
Bahn, Jae-Joon
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Seoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
Seoul Natl Univ, SNUMRC, Neurosci Res Inst, Program Neurosci, Seoul, South KoreaSeoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
Bahn, Jae-Joon
Jeon, Daejong
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机构:
Seoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
Seoul Natl Univ, Brain Korea Project Med Sci 21, Seoul, South KoreaSeoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
Jeon, Daejong
Kim, Manho
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h-index: 0
机构:
Seoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
Seoul Natl Univ, SNUMRC, Neurosci Res Inst, Program Neurosci, Seoul, South Korea
Seoul Natl Univ, Brain Korea Project Med Sci 21, Seoul, South KoreaSeoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
Kim, Manho
Lee, Sang Kun
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机构:
Seoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
Seoul Natl Univ, SNUMRC, Neurosci Res Inst, Program Neurosci, Seoul, South Korea
Seoul Natl Univ, Brain Korea Project Med Sci 21, Seoul, South KoreaSeoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
Lee, Sang Kun
Roh, Jae-Kyu
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Seoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
Seoul Natl Univ, SNUMRC, Neurosci Res Inst, Program Neurosci, Seoul, South Korea
Seoul Natl Univ, Brain Korea Project Med Sci 21, Seoul, South KoreaSeoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
机构:
Univ Roma La Sapienza, Dept Cell & Dev Biol, Res Ctr Neurosci Daniel Bovet, Rome, ItalyUniv Roma La Sapienza, Dept Cell & Dev Biol, Res Ctr Neurosci Daniel Bovet, Rome, Italy
Loreti, Simona
Ricordy, Ruggero
论文数: 0引用数: 0
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机构:
CNR, Inst Biol & Mol Pathol, Rome, ItalyUniv Roma La Sapienza, Dept Cell & Dev Biol, Res Ctr Neurosci Daniel Bovet, Rome, Italy
Ricordy, Ruggero
De Stefano, M. Egle
论文数: 0引用数: 0
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Univ Roma La Sapienza, Dept Cell & Dev Biol, Res Ctr Neurosci Daniel Bovet, Rome, ItalyUniv Roma La Sapienza, Dept Cell & Dev Biol, Res Ctr Neurosci Daniel Bovet, Rome, Italy
De Stefano, M. Egle
Augusti-Tocco, Gabriella
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Univ Roma La Sapienza, Dept Cell & Dev Biol, Res Ctr Neurosci Daniel Bovet, Rome, ItalyUniv Roma La Sapienza, Dept Cell & Dev Biol, Res Ctr Neurosci Daniel Bovet, Rome, Italy
Augusti-Tocco, Gabriella
Tata, Ada Maria
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Univ Roma La Sapienza, Dept Cell & Dev Biol, Res Ctr Neurosci Daniel Bovet, Rome, ItalyUniv Roma La Sapienza, Dept Cell & Dev Biol, Res Ctr Neurosci Daniel Bovet, Rome, Italy
机构:
Ctr Canc & Inflammat, Inst Canc, London EC1M 6BQ, England
Univ London St Bartholomews Hosp Med Coll, Sch Med & Dent, Canc Res UK Clin Ctr, London EC1M 6BQ, EnglandIRCCS, Ist Clin Humanitas, I-20089 Milan, Italy
机构:
Firat Univ, Fac Med, Dept Phys Med & Rehabil, Div Rheumatol, TR-23119 Elazig, TurkeyFirat Univ, Fac Med, Dept Phys Med & Rehabil, Div Rheumatol, TR-23119 Elazig, Turkey
Ozgocmen, S
Ozyurt, H
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机构:Firat Univ, Fac Med, Dept Phys Med & Rehabil, Div Rheumatol, TR-23119 Elazig, Turkey
Ozyurt, H
Sogut, S
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机构:Firat Univ, Fac Med, Dept Phys Med & Rehabil, Div Rheumatol, TR-23119 Elazig, Turkey
Sogut, S
Akyol, O
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机构:Firat Univ, Fac Med, Dept Phys Med & Rehabil, Div Rheumatol, TR-23119 Elazig, Turkey
机构:
Seoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
Seoul Natl Univ, SNUMRC, Neurosci Res Inst, Program Neurosci, Seoul, South KoreaSeoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
Lee, Soon-Tae
Chu, Kon
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h-index: 0
机构:
Seoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
Seoul Natl Univ, SNUMRC, Neurosci Res Inst, Program Neurosci, Seoul, South KoreaSeoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
Chu, Kon
Jung, Keun-Hwa
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h-index: 0
机构:
Seoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
Seoul Natl Univ, SNUMRC, Neurosci Res Inst, Program Neurosci, Seoul, South KoreaSeoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
Jung, Keun-Hwa
Kang, Kyung-Mook
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机构:
Seoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South KoreaSeoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
Kang, Kyung-Mook
Kim, Jin-Hee
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机构:
Seoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
Seoul Natl Univ, SNUMRC, Neurosci Res Inst, Program Neurosci, Seoul, South KoreaSeoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
Kim, Jin-Hee
Bahn, Jae-Joon
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机构:
Seoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
Seoul Natl Univ, SNUMRC, Neurosci Res Inst, Program Neurosci, Seoul, South KoreaSeoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
Bahn, Jae-Joon
Jeon, Daejong
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机构:
Seoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
Seoul Natl Univ, Brain Korea Project Med Sci 21, Seoul, South KoreaSeoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
Jeon, Daejong
Kim, Manho
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
Seoul Natl Univ, SNUMRC, Neurosci Res Inst, Program Neurosci, Seoul, South Korea
Seoul Natl Univ, Brain Korea Project Med Sci 21, Seoul, South KoreaSeoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
Kim, Manho
Lee, Sang Kun
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h-index: 0
机构:
Seoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
Seoul Natl Univ, SNUMRC, Neurosci Res Inst, Program Neurosci, Seoul, South Korea
Seoul Natl Univ, Brain Korea Project Med Sci 21, Seoul, South KoreaSeoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
Lee, Sang Kun
Roh, Jae-Kyu
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h-index: 0
机构:
Seoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
Seoul Natl Univ, SNUMRC, Neurosci Res Inst, Program Neurosci, Seoul, South Korea
Seoul Natl Univ, Brain Korea Project Med Sci 21, Seoul, South KoreaSeoul Natl Univ Hosp, Dept Neurol, Stem Cell Res Ctr, Stroke & Stem Cell Lab,Clin Res Inst, Seoul 110744, South Korea
机构:
Univ Roma La Sapienza, Dept Cell & Dev Biol, Res Ctr Neurosci Daniel Bovet, Rome, ItalyUniv Roma La Sapienza, Dept Cell & Dev Biol, Res Ctr Neurosci Daniel Bovet, Rome, Italy
Loreti, Simona
Ricordy, Ruggero
论文数: 0引用数: 0
h-index: 0
机构:
CNR, Inst Biol & Mol Pathol, Rome, ItalyUniv Roma La Sapienza, Dept Cell & Dev Biol, Res Ctr Neurosci Daniel Bovet, Rome, Italy
Ricordy, Ruggero
De Stefano, M. Egle
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Dept Cell & Dev Biol, Res Ctr Neurosci Daniel Bovet, Rome, ItalyUniv Roma La Sapienza, Dept Cell & Dev Biol, Res Ctr Neurosci Daniel Bovet, Rome, Italy
De Stefano, M. Egle
Augusti-Tocco, Gabriella
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Dept Cell & Dev Biol, Res Ctr Neurosci Daniel Bovet, Rome, ItalyUniv Roma La Sapienza, Dept Cell & Dev Biol, Res Ctr Neurosci Daniel Bovet, Rome, Italy
Augusti-Tocco, Gabriella
Tata, Ada Maria
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Dept Cell & Dev Biol, Res Ctr Neurosci Daniel Bovet, Rome, ItalyUniv Roma La Sapienza, Dept Cell & Dev Biol, Res Ctr Neurosci Daniel Bovet, Rome, Italy
机构:
Ctr Canc & Inflammat, Inst Canc, London EC1M 6BQ, England
Univ London St Bartholomews Hosp Med Coll, Sch Med & Dent, Canc Res UK Clin Ctr, London EC1M 6BQ, EnglandIRCCS, Ist Clin Humanitas, I-20089 Milan, Italy
机构:
Firat Univ, Fac Med, Dept Phys Med & Rehabil, Div Rheumatol, TR-23119 Elazig, TurkeyFirat Univ, Fac Med, Dept Phys Med & Rehabil, Div Rheumatol, TR-23119 Elazig, Turkey
Ozgocmen, S
Ozyurt, H
论文数: 0引用数: 0
h-index: 0
机构:Firat Univ, Fac Med, Dept Phys Med & Rehabil, Div Rheumatol, TR-23119 Elazig, Turkey
Ozyurt, H
Sogut, S
论文数: 0引用数: 0
h-index: 0
机构:Firat Univ, Fac Med, Dept Phys Med & Rehabil, Div Rheumatol, TR-23119 Elazig, Turkey
Sogut, S
Akyol, O
论文数: 0引用数: 0
h-index: 0
机构:Firat Univ, Fac Med, Dept Phys Med & Rehabil, Div Rheumatol, TR-23119 Elazig, Turkey