You may need the vagus nerve to understand pathophysiology and to treat diseases
被引:64
作者:
De Couck, Marijke
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机构:
Vrije Univ Brussel, Fac Med & Pharm, Brussels, BelgiumVrije Univ Brussel, Fac Med & Pharm, Brussels, Belgium
De Couck, Marijke
[1
]
Mravec, Boris
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机构:
Comenius Univ, Fac Med, Inst Pathophysiol, Bratislava, Slovakia
Slovak Acad Sci, Inst Expt Endocrinol, Bratislava, SlovakiaVrije Univ Brussel, Fac Med & Pharm, Brussels, Belgium
Mravec, Boris
[2
,3
]
Gidron, Yori
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机构:
Vrije Univ Brussel, Fac Med & Pharm, Brussels, BelgiumVrije Univ Brussel, Fac Med & Pharm, Brussels, Belgium
Gidron, Yori
[1
]
机构:
[1] Vrije Univ Brussel, Fac Med & Pharm, Brussels, Belgium
[2] Comenius Univ, Fac Med, Inst Pathophysiol, Bratislava, Slovakia
[3] Slovak Acad Sci, Inst Expt Endocrinol, Bratislava, Slovakia
Can different pathophysiological mechanisms and risk factors leading to various diseases be linked with altered transmission of signals by one common pathway? The present article provides evidence for the hypothesis that adequate vagal nerve activity reduces the risk of major diseases, via common basic mechanisms and interim risk factors. These diseases include cardiovascular disease, cancer, Alzheimer's disease and the metabolic syndrome. Three basic mechanisms contribute to such illnesses: local oxidative stress and DNA damage, inflammatory reactions and excessive sympathetic responses, all of which are inhibited by vagal nerve activity. Efferent vagal activity that can be non-invasively measured by HRV (heart rate variability), derived from an ECG, is inversely related to all three basic mechanisms, to various risk factors (e.g. diabetes and dyslipidaemia) and, more broadly, to the diseases as well. Finally, vagal activity is proposed to moderate the effects of risk factors on developing such illnesses. By proposing an integrative neurobiological model of major diseases, identifying people at risk for, and treating patients with, such diseases may be done more efficiently. People with low HRV may be identified and subsequently treated by vagus nerve activation to possibly prevent or treat such illnesses. This proposed disease paradigm may have important preventative and therapeutic implications, whose clinical effects need to be investigated.
机构:
Buddhist Dalin Tzu Chi Gen Hosp, Dept Family Med, Chiayi, Taiwan
Nanhua Univ, Dept Nat Biotechnol, Chiayi, TaiwanBuddhist Dalin Tzu Chi Gen Hosp, Dept Family Med, Chiayi, Taiwan
Chiang, Jui-Kun
Koo, Malcolm
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机构:
Nanhua Univ, Grad Inst Nat Healing Sci, Chiayi, TaiwanBuddhist Dalin Tzu Chi Gen Hosp, Dept Family Med, Chiayi, Taiwan
Koo, Malcolm
Kuo, Terry B. J.
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机构:
Natl Yang Ming Univ, Inst Brain Sci, Taipei 112, TaiwanBuddhist Dalin Tzu Chi Gen Hosp, Dept Family Med, Chiayi, Taiwan
Kuo, Terry B. J.
Fu, Chin-Hua
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机构:
Buddhist Taichung Tzu Chi Gen Hosp, Dept Neurol, Taichung, Taiwan
Tzu Chi Univ, Sch Med, Hualien, TaiwanBuddhist Dalin Tzu Chi Gen Hosp, Dept Family Med, Chiayi, Taiwan
机构:
Univ Brasilia, Brasilia Univ Hosp, Med Sci Postgrad Course, Geriatr Med Ctr, BR-70910900 Brasilia, DF, BrazilUniv Brasilia, Fac Med, Clin Med Area, Med Sci Postgrad Course,Cardiovasc Lab, BR-70910900 Brasilia, DF, Brazil
de Vilhena Toledo, Maria Alice
Junqueira, Luiz Fernando, Jr.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Brasilia, Fac Med, Clin Med Area, Med Sci Postgrad Course,Cardiovasc Lab, BR-70910900 Brasilia, DF, Brazil
Univ Brasilia, Brasilia Univ Hosp, Div Cardiol, BR-70910900 Brasilia, DF, BrazilUniv Brasilia, Fac Med, Clin Med Area, Med Sci Postgrad Course,Cardiovasc Lab, BR-70910900 Brasilia, DF, Brazil
机构:
Akdeniz Univ, Dept Internal Med, TR-07058 Antalya, TurkeyPenn State Univ, Gittlen Canc Res Fdn, Hershey Med Ctr, Hershey, PA 17033 USA
Erin, Nuray
Barkan, Gueliz Akdas
论文数: 0引用数: 0
h-index: 0
机构:
Loyola Univ, Stritch Sch Med, Dept Pathol, Maywood, IL 60153 USAPenn State Univ, Gittlen Canc Res Fdn, Hershey Med Ctr, Hershey, PA 17033 USA
Barkan, Gueliz Akdas
Harms, John F.
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机构:Penn State Univ, Gittlen Canc Res Fdn, Hershey Med Ctr, Hershey, PA 17033 USA
Harms, John F.
Clawson, Gary A.
论文数: 0引用数: 0
h-index: 0
机构:
Penn State Univ, Gittlen Canc Res Fdn, Hershey Med Ctr, Hershey, PA 17033 USA
Penn State Univ, Dept Pathol Biochem & Mol Biol, Hershey, PA 17033 USA
SW Univ Nationalities China, Chengdu 610041, Sichuan, Peoples R ChinaPenn State Univ, Gittlen Canc Res Fdn, Hershey Med Ctr, Hershey, PA 17033 USA
机构:
Buddhist Dalin Tzu Chi Gen Hosp, Dept Family Med, Chiayi, Taiwan
Nanhua Univ, Dept Nat Biotechnol, Chiayi, TaiwanBuddhist Dalin Tzu Chi Gen Hosp, Dept Family Med, Chiayi, Taiwan
Chiang, Jui-Kun
Koo, Malcolm
论文数: 0引用数: 0
h-index: 0
机构:
Nanhua Univ, Grad Inst Nat Healing Sci, Chiayi, TaiwanBuddhist Dalin Tzu Chi Gen Hosp, Dept Family Med, Chiayi, Taiwan
Koo, Malcolm
Kuo, Terry B. J.
论文数: 0引用数: 0
h-index: 0
机构:
Natl Yang Ming Univ, Inst Brain Sci, Taipei 112, TaiwanBuddhist Dalin Tzu Chi Gen Hosp, Dept Family Med, Chiayi, Taiwan
Kuo, Terry B. J.
Fu, Chin-Hua
论文数: 0引用数: 0
h-index: 0
机构:
Buddhist Taichung Tzu Chi Gen Hosp, Dept Neurol, Taichung, Taiwan
Tzu Chi Univ, Sch Med, Hualien, TaiwanBuddhist Dalin Tzu Chi Gen Hosp, Dept Family Med, Chiayi, Taiwan
机构:
Univ Brasilia, Brasilia Univ Hosp, Med Sci Postgrad Course, Geriatr Med Ctr, BR-70910900 Brasilia, DF, BrazilUniv Brasilia, Fac Med, Clin Med Area, Med Sci Postgrad Course,Cardiovasc Lab, BR-70910900 Brasilia, DF, Brazil
de Vilhena Toledo, Maria Alice
Junqueira, Luiz Fernando, Jr.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Brasilia, Fac Med, Clin Med Area, Med Sci Postgrad Course,Cardiovasc Lab, BR-70910900 Brasilia, DF, Brazil
Univ Brasilia, Brasilia Univ Hosp, Div Cardiol, BR-70910900 Brasilia, DF, BrazilUniv Brasilia, Fac Med, Clin Med Area, Med Sci Postgrad Course,Cardiovasc Lab, BR-70910900 Brasilia, DF, Brazil
机构:
Akdeniz Univ, Dept Internal Med, TR-07058 Antalya, TurkeyPenn State Univ, Gittlen Canc Res Fdn, Hershey Med Ctr, Hershey, PA 17033 USA
Erin, Nuray
Barkan, Gueliz Akdas
论文数: 0引用数: 0
h-index: 0
机构:
Loyola Univ, Stritch Sch Med, Dept Pathol, Maywood, IL 60153 USAPenn State Univ, Gittlen Canc Res Fdn, Hershey Med Ctr, Hershey, PA 17033 USA
Barkan, Gueliz Akdas
Harms, John F.
论文数: 0引用数: 0
h-index: 0
机构:Penn State Univ, Gittlen Canc Res Fdn, Hershey Med Ctr, Hershey, PA 17033 USA
Harms, John F.
Clawson, Gary A.
论文数: 0引用数: 0
h-index: 0
机构:
Penn State Univ, Gittlen Canc Res Fdn, Hershey Med Ctr, Hershey, PA 17033 USA
Penn State Univ, Dept Pathol Biochem & Mol Biol, Hershey, PA 17033 USA
SW Univ Nationalities China, Chengdu 610041, Sichuan, Peoples R ChinaPenn State Univ, Gittlen Canc Res Fdn, Hershey Med Ctr, Hershey, PA 17033 USA