Chitooligosaccharides induce apoptosis in human myeloid leukemia HL-60 cells

被引：38
|
作者：
Kim, Eun-Kyung [2 ,4 ]
Je, Jae-Young [3 ]
Lee, Seung-Jae [1 ]
Kim, Yon-Suk [1 ]
Hwang, Jin-Woo [1 ]
Sung, Si-Heung [2 ]
Moon, Sang-Ho [4 ]
Jeon, Byong-Tae [4 ]
Kim, Se-Kwon [5 ]
Jeon, You-Jin [6 ]
Park, Pyo-Jam [1 ,4 ]
机构：
[1] Konkuk Univ, Dept Biotechnol, Chungju 380701, South Korea
[2] Konkuk Univ, Dept Food Life Sci, Chungju 380701, South Korea
[3] Chonnam Natl Univ, Dept Food Technol & Nutr, Yeosu 350749, South Korea
[4] Konkuk Univ, Korean Nokyong Res Ctr, Chungju 380701, South Korea
[5] Pukyong Natl Univ, Dept Chem, Pusan 608737, South Korea
[6] Jeju Natl Univ, Fac Appl Marine Sci, Cheju 690756, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 19期
关键词：
Hetero-chitooligosaccharide; Deacetylation; Molecular weight; Anticancer; HETERO-CHITOOLIGOSACCHARIDES; ANTIMICROBIAL ACTIVITY; CHITOSAN; CANCER; PREVENTION; WEIGHT;
D O I：
10.1016/j.bmcl.2012.08.030
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In this study we propose a novel anticancer agent using hetero-chitooligosaccharide (hetero-COS). To examine the possibility of the hetero-COS as a anticancer agent, we prepared nine kinds of hetero-COS with relatively higher molecular weights (90, 75 and 50-COS I, 5 similar to 10 kDa), medium molecular weights (90, 75 and 50-COS II, 1 similar to 5 kDa), and lower molecular weights (90, 75 and 50-III, below 1 kDa), and their anticancer properties were investigated on HL-60 cells using flow cytometry and morphological analysis. The results obtained indicate that 90-COS III, which is relatively higher degree of deacetylation and lower molecular weights, showed the highest anticancer activity, and the data showed the anticancer property of the hetero-COSs depended on their degree of deacetylation values and molecular weight. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6136 / 6138
页数：3
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