Autophagy, Myocardial Protection, and the Metabolic Syndrome

被引：38

作者：

Giricz, Zoltan ^{[1
]}

Mentzer, Robert M., Jr. ^{[1
,2
,3
]}

Gottlieb, Roberta A. ^{[1
]}

机构：

[1] San Diego State Univ, Donald P Shiley BioSci Ctr, Dept Biol, San Diego, CA 92182 USA

[2] Wayne State Univ, Sch Med, Dept Physiol, Cardiovasc Res Inst, Detroit, MI 48201 USA

[3] Wayne State Univ, Sch Med, Dept Surg, Detroit, MI 48201 USA

来源：

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 2012年 / 60卷 / 02期

关键词：

autophagy; cardioprotection; metabolic syndrome; myocardial ischemia and reperfusion; ACTIVATED PROTEIN-KINASE; ISCHEMIA-REPERFUSION INJURY; TERM CALORIC RESTRICTION; OXIDATIVE STRESS; DIABETIC HEART; ISCHEMIA/REPERFUSION INJURY; MITOCHONDRIAL DYSFUNCTION; ROSIGLITAZONE TREATMENT; DIFFERENTIAL ROLES; INSULIN-RESISTANCE;

D O I：

10.1097/FJC.0b013e318256ce10

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Autophagy is a housekeeping process that helps to maintain cellular energy homeostasis and remove damaged organelles. In the heart, autophagy is an adaptive process that is activated in response to stress including acute and chronic ischemia. Given the evidence that autophagy is suppressed in energy-rich conditions, the objective of this review is to examine autophagy and cardioprotection in the setting of the metabolic syndrome. Clinical approaches that involve the induction of cardiac autophagy pharmacologically to enhance the heart's tolerance to ischemia are also discussed.

引用

页码：125 / 132

页数：8

共 50 条

[31] Role of Autophagy in the Pathogenesis of Diabetes and Therapeutic Potential of Autophagy Modulators in the Treatment of Diabetes and Metabolic Syndrome
Oh, Soo-Jin
Lee, Myung-Shik
JOURNAL OF KOREAN MEDICAL SCIENCE, 2022, 37 (37)
[32] Up-regulated autophagy: as a protective factor in adipose tissue of WOKW rats with metabolic syndrome
Kosacka, J.
Nowicki, M.
Paeschke, S.
Baum, P.
Blueher, M.
Kloeting, N.
DIABETOLOGY & METABOLIC SYNDROME, 2018, 10
[33] Mitochondrial dysfunction in metabolic syndrome
Prasun, Pankaj
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2020, 1866 (10):
[34] Nutrapharmacology of Tocotrienols for Metabolic Syndrome
Weng-Yew, Wong
Brown, Lindsay
CURRENT PHARMACEUTICAL DESIGN, 2011, 17 (21) : 2206 - 2214
[35] Myocardial protection by nitrite
Calvert, John W.
Lefer, David J.
CARDIOVASCULAR RESEARCH, 2009, 83 (02) : 195 - 203
[36] Tetramethylprazine attenuates myocardial ischemia/reperfusion injury through modulation of autophagy
Zuo, Zhi
Zuo, Peng-fei
Sheng, Zu-long
Wang, Xin
Ding, Jian-dong
Ma, Gen-shan
LIFE SCIENCES, 2019, 239
[37] Autophagy and mitophagy in cancer metabolic remodelling
Ferro, Fabio
Servais, Stephane
Besson, Pierre
Roger, Sebastien
Dumas, Jean-Francois
Brisson, Lucie
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2020, 98 : 129 - 138
[38] Molecular mechanisms for myocardial mitochondrial dysfunction in the metabolic syndrome
Bugger, Heiko
Abel, E. Dale
CLINICAL SCIENCE, 2008, 114 (3-4) : 195 - 210
[39] Obesity and the metabolic syndrome in patients with acute myocardial infarction
Prasad, Sandhir B.
Fahrtash, Farzan
Malaiapan, Yuvaraj
Meredith, Ian T.
Cameron, James
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2010, 144 (03) : 450 - 451
[40] The impact of metabolic syndrome on left ventricular myocardial performance
Voulgari, Christina
Moyssakis, Ioannis
Papazafiropoulou, Athanasia
Perrea, Despoina
Kyriaki, Despoina
Katsilambros, Nicholas
Tentolouris, Nicholas
DIABETES-METABOLISM RESEARCH AND REVIEWS, 2010, 26 (02) : 121 - 127

← 1 2 3 4 5 →