Effects of fermented barley on lipid and carnitine profiles in C57BL/6J mice

被引：4

作者：

Choi, Ji-Hae ^{[1
,2
]}

Kim, Tae-Hee ^{[3
]}

Ko, Myung-Suk ^{[3
]}

Cha, Youn-Soo ^{[1
,2
]}

机构：

[1] Chonbuk Natl Univ, Dept Food Sci & Human Nutr, Jeonju 561756, Jeonbuk, South Korea

[2] Chonbuk Natl Univ, Res Inst Human Ecol, Jeonju 561756, Jeonbuk, South Korea

[3] Barley & Oats Co Ltd, Jeongeup 580812, Jeonbuk, South Korea

来源：

FOOD SCIENCE AND BIOTECHNOLOGY | 2012年 / 21卷 / 02期

关键词：

barley; mice; lipid profile; carnitine; hepatic mRNA level; HIGH-FAT DIET; BETA-GLUCAN; OBESITY; ACID; COA; FIBER; RISK; CHOLESTEROL; INVOLVEMENT; PERSPECTIVE;

D O I：

10.1007/s10068-012-0043-z

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The aim of the present study was to investigate the effects of fermented barley supplementation on blood lipid profiles, carnitine concentrations, and hepatic mRNA levels of enzymes involved in fatty acid metabolism. Thirty-two C57BL/6J male mice were divided into 4 groups; normal diet control group (ND), high fat diet control group (HD), high fat diet plus barley supplemented group (BR), and high fat diet plus fermented barley supplemented group (BR-F). BR-F supplementations decreased total cholesterol (TC) and LDL-cholesterol in serum, triglyceride (TG) in liver. Serum total carnitine (TCNE) concentrations were significantly higher in the BR-F group than HD group. BR-F supplementations significantly increased hepatic lipolysis regulating gene expression such as carnitine palmitoyltransferase-I (CPT-I), peroxisome proliferator-activated receptor-alpha (PPAR alpha), whereas significantly decreased lipogenic enzyme expression such as acetyl CoA carboxylase (ACC). These results suggest that the fermented barley has anti-obesity properties.

引用

页码：323 / 329

页数：7

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