Cysteine-derived organocatalyst in a highly enantioselective intramolecular Michael reaction

被引：198

作者：

Hayashi, Y ^{[1
]}

Gotoh, H ^{[1
]}

Tamura, T ^{[1
]}

Yamaguchi, H ^{[1
]}

Masui, R ^{[1
]}

Shoji, M ^{[1
]}

机构：

[1] Tokyo Univ Sci, Fac Engn, Dept Ind Chem, Shinjuku Ku, Tokyo 1628601, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 46期

关键词：

D O I：

10.1021/ja055740s

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Asymmetric intramolecular Michael reaction catalyzed by an organocatalyst derived from cysteine has been developed for the synthesis of chiral bicyclo[4.3.0]nonene and cis-disubstituted cyclopentane skeletons with a creation of three or two contiguous chiral centers in good yield with high diastereo- and excellent enantioselectivities. Copyright © 2005 American Chemical Society.

引用

页码：16028 / 16029

页数：2

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