Amaryllidaceae Alkaloids from Clivia miniata (Lindl.) Bosse (Amaryllidaceae): Isolation, Structural Elucidation, and Biological Activity

被引：5

作者：

Safratova, Marcela ^{[1
]}

Kroustkova, Jana ^{[1
]}

Maafi, Negar ^{[1
]}

Suchankova, Daniela ^{[1
]}

Vrabec, Rudolf ^{[1
]}

Chlebek, Jakub ^{[1
]}

Kunes, Jiri ^{[2
]}

Opletal, Lubomir ^{[1
]}

Bucar, Franz ^{[3
]}

Cahlikova, Lucie ^{[1
]}

机构：

[1] Charles Univ Prague, Fac Pharm, Dept Pharmacognosy & Pharmaceut Bot, Heyrovskeho 1203, Hradec Kralove 50005, Czech Republic

[2] Charles Univ Prague, Fac Pharm, Dept Bioorgan & Organ Chem, Heyrovskeho 1203, Hradec Kralove 50005, Czech Republic

[3] Karl Franzens Univ Graz, Inst Pharmaceut Sci, Beethovenstr 8, A-8010 Graz, Austria

来源：

PLANTS-BASEL | 2022年 / 11卷 / 22期

关键词：

acetylcholinesterase; Amaryllidaceae; butyrylcholinesterase; Clivia miniata; clivimine B; ACETYLCHOLINESTERASE; NOBILISITINE; INHIBITORS; BULBS;

D O I：

10.3390/plants11223034

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Clivia miniata (Amaryllidaceae) is an herbaceous evergreen flowering plant that is endemic to South Africa and Swaziland and belongs to one of the top-10 traded medicinal plants in informal medicine markets in South Africa. The species has been reported as the most important component of a traditional healer's pallet of healing plants. Eighteen known Amaryllidaceae alkaloids (AAs) of various structural types, and one undescribed alkaloid of homolycorine-type, named clivimine B (3), were isolated from Clivia miniata. The chemical structures of the isolated alkaloids were elucidated by a combination of MS, HRMS, 1D and 2D NMR techniques and by comparison with literature data. Compounds isolated in a sufficient quantity, and not tested previously, were evaluated for their in vitro acetylcholinesterase (AChE; E.C. 3.1.1.7) and butyrylcholinesterase (BuChE; E.C. 3.1.1.8) inhibition activities.

引用

页数：12

共 41 条

[1] Amaryllidaceae Alkaloids of Belladine-Type from Narcissus pseudonarcissus cv. Carlton as New Selective Inhibitors of Butyrylcholinesterase [J].

Al Mamun, Abdullah ;

Marikova, Jana ;

Hulcova, Daniela ;

Janousek, Jiri ;

Safratova, Marcela ;

Novakova, Lucie ;

Kucera, Tomas ;

Hrabinova, Martina ;

Kunes, Jiri ;

Korabecny, Jan ;

Cahlikova, Lucie .

BIOMOLECULES, 2020, 10 (05)

[2] Amaryllidaceae alkaloids from Hippeastrum X Hybridum CV. Ferrari, and preparation of vittatine derivatives as potential ligands for Alzheimer's disease [J].

Al Shammari, L. ;

Hulcova, D. ;

Marikova, J. ;

Kucera, T. ;

Safratova, M. ;

Novakova, L. ;

Schmidt, M. ;

Pulkrabkova, L. ;

Janousek, J. ;

Soukup, O. ;

Kunes, J. ;

Opletal, L. ;

Cahlikova, L. .

SOUTH AFRICAN JOURNAL OF BOTANY, 2021, 136 :137-146

[3] CLIVONIDINE, A NEW ALKALOID FROM CLIVIA-MINIATA [J].

ALI, AA ;

ROSS, SA ;

ELMOGHAZY, AM ;

ELMOGHAZY, SA .

JOURNAL OF NATURAL PRODUCTS, 1983, 46 (03) :350-352

[4]

Bastida J, 2006, ALKALOIDS-CHEM BIOL, V63, P87, DOI 10.1016/S1099-4831(06)63003-4

[5] Amaryllidaceae Alkaloids of Different Structural Types from Narcissus L. cv. Professor Einstein and Their Cytotoxic Activity [J].

Breiterova, Katerina ;

Koutova, Darja ;

Marikova, Jana ;

Havelek, Radim ;

Kunes, Jiri ;

Majorosova, Martina ;

Opletal, Lubomir ;

Host'alkova, Anna ;

Jenco, Jaroslav ;

Rezacova, Martina ;

Cahlikova, Lucie .

PLANTS-BASEL, 2020, 9 (02)

[6] The Amaryllidaceae alkaloids haemanthamine, haemanthidine and their semisynthetic derivatives as potential drugs [J].

Cahlikova, Lucie ;

Kawano, Ippei ;

Rezacova, Martina ;

Blunden, Gerald ;

Hulcova, Daniela ;

Havelek, Radim .

PHYTOCHEMISTRY REVIEWS, 2021, 20 (01) :303-323

[7]

Cahlíková L, 2013, NAT PROD COMMUN, V8, P1541

[8] Comprehensive Study of Alkaloids from Crinum asiaticum var. sinicum Assisted by HPLC-DAD-SPE-NMR [J].

Chen, Chien-Kuang ;

Lin, Feng-Hsu ;

Tseng, Li-Hong ;

Jiang, Chia-Ling ;

Lee, Shoei-Sheng .

JOURNAL OF NATURAL PRODUCTS, 2011, 74 (03) :411-419

[9] Total Synthesis of (-)-Galanthamine and (-)-Lycoramine via Catalytic Asymmetric Hydrogenation and Intramolecular Reductive Heck Cyclization [J].

Chen, Ji-Qiang ;

Xie, Jian-Hua ;

Bao, Deng-Hui ;

Liu, Sheng ;

Zhou, Qi-Lin .

ORGANIC LETTERS, 2012, 14 (11) :2714-2717

[10] Antiplasmodial alkaloids from bulbs of Amaryllis belladonna Steud [J].

Cho, Namki ;

Du, Yongle ;

Valenciano, Ana Lisa ;

Fernandez-Murga, Maria L. ;

Goetz, Michael ;

Clement, Jason ;

Cassera, Maria B. ;

Kingston, David G. I. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 28 (01) :40-42

← 1 2 3 4 5 →