Role of Bacterial Exopolysaccharides as Agents in Counteracting Immune Disorders Induced by Herpes Virus

被引：30

作者：

Gugliandolo, Concetta ^{[1
]}

Spano, Antonio ^{[1
]}

Maugeri, Teresa L. ^{[1
]}

Poli, Annarita ^{[1
,2
]}

Arena, Adriana ^{[1
,3
]}

Nicolaus, Barbara ^{[1
,2
]}

机构：

[1] Univ Messina, Res Ctr Extreme Environm & Extremophiles, Dept Biol & Environm Sci, Vle F Stagno Dalcontres 31, I-98166 Messina, Italy

[2] Council Natl Res CNR, Inst Biomol Chem, Via Campi Flegrei 34, I-80078 Pozzuoli, Italy

[3] Policlin Univ G Martino, Dept Human Pathol, Unit Clin Microbiol, Via Consolare Valeria, I-98125 Messina, Italy

来源：

MICROORGANISMS | 2015年 / 3卷 / 03期

关键词：

antivirals; Eolian Islands; exopolysaccharides; herpes simplex virus; immunomodulators; extremophiles; shallow marine vents;

D O I：

10.3390/microorganisms3030464

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Extreme marine environments, such as the submarine shallow vents of the Eolian Islands (Italy), offer an almost unexplored source of microorganisms producing unexploited and promising biomolecules for pharmaceutical applications. Thermophilic and thermotolerant bacilli isolated from Eolian vents are able to produce exopolysaccharides (EPSs) with antiviral and immunomodulatory effects against Herpes simplex virus type 2 (HSV-2). HSV-2 is responsible for the most common and continuously increasing viral infections in humans. Due to the appearance of resistance to the available treatments, new biomolecules exhibiting different mechanisms of action could provide novel agents for treating viral infections. The EPSs hinder the HSV-2 replication in human peripheral blood mononuclear cells (PBMC) but not in WISH (Wistar Institute Susan Hayflic) cells line, indicating that cell-mediated immunity was involved in the antiviral activity. High levels of Th1-type cytokines were detected in PBMC treated with all EPSs, while Th2-type cytokines were not induced. These EPSs are water soluble exopolymers able to stimulate the immune response and thus contribute to the antiviral immune defense, acting as immunomodulators. As stimulants of Th1 cell-mediated immunity, they could lead to the development of novel drugs as alternative in the treatment of herpes virus infections, as well as in immunocompromised host.

引用

页码：464 / 483

页数：20

共 57 条

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