Synthesis, Crystal Structure and Antiproliferative Activity of Ethyl 1-(Phenylcarbamoyl)-2-3,4,5-trimethoxyphenyl)cyclopropanecarboxylae

被引:0
作者
Zhang Jing-Yi [1 ]
Zhong Han-Yu [2 ]
Shi Guo-Bing [1 ]
机构
[1] Shenyang Mil Command, Gen Hosp, Dept Pharm, Shenyang 110016, Peoples R China
[2] China Med Univ, Affiliated Hosp 1, Dept Pharm, Shenyang 110001, Peoples R China
关键词
3,4,5-trimethoxyphenyl; synthesis; crystal structure; antiproliferative activities; ANTITUMOR-ACTIVITY; DERIVATIVES;
D O I
暂无
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Many small-molecule compounds have been evaluated with potential antiproliferative activities. Ethyl 1-(phenylcarbamoyl)-2-(3,4,5-trimethoxyphenyl)cyclopropanecarboxylate, one novel cyclopropylamide analogue of combretastatin-A4 (CA-4), has been synthesized and its crystal structure was characterized by X-ray single-crystal diffraction. The crystal belongs to monoclinic, space group P2(1)/n, with a = 15.0263(3), b = 7.6574(2), c = 19.4117(4) angstrom, beta = 111.9010(10), V= 2072.36(8) angstrom(3), Z = 4, C22H24NO6, M-r = 398.42, D-c, = 1.277 Mg/cm(3), F(000) = 844, lambda(MoK alpha) = 1.54178 angstrom, mu = 0.770 mm(-1), R= 0.0546 and wR = 0.1889 for 3319 observed -reflections (I> 2 sigma(I)). Meanwhile, the compound revealed potential antiproliferative activities in several cancer cells in vitro.
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页码:876 / 880
页数:5
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