Synthesis, Crystal Structure and Antiproliferative Activity of Ethyl 1-(Phenylcarbamoyl)-2-3,4,5-trimethoxyphenyl)cyclopropanecarboxylae

被引：0

作者：

Zhang Jing-Yi ^{[1
]}

Zhong Han-Yu ^{[2
]}

Shi Guo-Bing ^{[1
]}

机构：

[1] Shenyang Mil Command, Gen Hosp, Dept Pharm, Shenyang 110016, Peoples R China

[2] China Med Univ, Affiliated Hosp 1, Dept Pharm, Shenyang 110001, Peoples R China

来源：

CHINESE JOURNAL OF STRUCTURAL CHEMISTRY | 2014年 / 33卷 / 06期

关键词：

3,4,5-trimethoxyphenyl; synthesis; crystal structure; antiproliferative activities; ANTITUMOR-ACTIVITY; DERIVATIVES;

D O I：

暂无

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Many small-molecule compounds have been evaluated with potential antiproliferative activities. Ethyl 1-(phenylcarbamoyl)-2-(3,4,5-trimethoxyphenyl)cyclopropanecarboxylate, one novel cyclopropylamide analogue of combretastatin-A4 (CA-4), has been synthesized and its crystal structure was characterized by X-ray single-crystal diffraction. The crystal belongs to monoclinic, space group P2(1)/n, with a = 15.0263(3), b = 7.6574(2), c = 19.4117(4) angstrom, beta = 111.9010(10), V= 2072.36(8) angstrom(3), Z = 4, C22H24NO6, M-r = 398.42, D-c, = 1.277 Mg/cm(3), F(000) = 844, lambda(MoK alpha) = 1.54178 angstrom, mu = 0.770 mm(-1), R= 0.0546 and wR = 0.1889 for 3319 observed -reflections (I> 2 sigma(I)). Meanwhile, the compound revealed potential antiproliferative activities in several cancer cells in vitro.

引用

页码：876 / 880

页数：5

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