Lipid oligonucleotide conjugates as responsive nanomaterials for drug delivery

被引:36
|
作者
Pokholenko, Oleksandr [1 ,2 ]
Gissot, Arnaud [1 ,2 ]
Vialet, Brune [1 ,2 ]
Bathany, Katell [3 ]
Thiery, Alain [4 ]
Barthelemy, Philippe [1 ,2 ]
机构
[1] Univ Bordeaux Segalen, F-33076 Bordeaux, France
[2] INSERM, U869, F-33076 Bordeaux, France
[3] Univ Bordeaux, CBMN UMR 5248, F-33600 Pessac, France
[4] Aix Marseille Univ, UMR CNRS IMBE 7263, Marseille, France
关键词
NUCLEIC-ACIDS; DNA; MICELLES; AMPHIPHILES; MEMBRANES; HYBRID; HYBRIDIZATION; NANOCARRIERS; ASSEMBLIES; COPOLYMERS;
D O I
10.1039/c3tb20357c
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
We report Lipid OligoNucleotide conjugates (LONs) bearing either two or three hydrophobic chains. LONs self-assemble into micellar aggregates, which provide a suitable reservoir for hydrophobic drugs such as paclitaxel. Our results demonstrate that the composition of the LONs both in terms of the lipid and the oligonucleotide sequence impacts their ability to host lipophilic molecules. Interestingly, binding of the complementary oligonucleotide selectively induces the release of part of the drug payload of the aggregates. These LON based micelles, which efficiently host hydrophobic drugs, represent an original stimuli-responsive drug delivery system.
引用
收藏
页码:5329 / 5334
页数:6
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